2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol

Base Information

Chemical Name:2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol
CAS No.:886228-60-0
Molecular Formula:C₁₆H₂₅FO₂Si
Molecular Weight:296.457
Hs Code.:

2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol

Synonyms:2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol

Chemical Property:

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Technology Process of 2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol

There total 5 articles about 2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 886228-73-5
2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-acrylic acid methyl ester

: 886228-60-0
2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane;
DOI:10.1055/s-2006-932489

Reference yield:

: 1010396-60-7
methyl (Z)-4-(bromomethyl)-3-(4-fluorophenyl)-2-propenoate

: 886228-60-0
2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / acetonitrile / Heating

2: aq. HCl / methanol

3: 100 percent / imidazole / dimethylformamide

4: 86 percent / DIBAL-H / CH₂Cl₂

With 1H-imidazole; hydrogenchloride; diisobutylaluminium hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-2006-932489

Reference yield:

: 3-(4-fluoro-phenyl)-2-formyloxymethyl-acrylic acid methyl ester

: 886228-60-0
2-(tert-butyl-dimethyl-silanyloxymethyl)-3-(4-fluoro-phenyl)-prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl / methanol

2: 100 percent / imidazole / dimethylformamide

3: 86 percent / DIBAL-H / CH₂Cl₂

With 1H-imidazole; hydrogenchloride; diisobutylaluminium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-932489