(4-Amino-3-methylamino-phenyl)-thiophen-2-yl-methanone; hydrochloride

Base Information

Chemical Name:(4-Amino-3-methylamino-phenyl)-thiophen-2-yl-methanone; hydrochloride
CAS No.:117498-58-5
Molecular Formula:C₁₂H₁₂N₂OS*ClH
Molecular Weight:268.767
Hs Code.:

Synonyms:(4-Amino-3-methylamino-phenyl)-thiophen-2-yl-methanone; hydrochloride

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Chemical Property of (4-Amino-3-methylamino-phenyl)-thiophen-2-yl-methanone; hydrochloride

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Technology Process of (4-Amino-3-methylamino-phenyl)-thiophen-2-yl-methanone; hydrochloride

There total 4 articles about (4-Amino-3-methylamino-phenyl)-thiophen-2-yl-methanone; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117498-40-5
<3-(methylamino)-4-nitrophenyl>(2-thienyl)methanone

: 117498-58-5
(4-Amino-3-methylamino-phenyl)-thiophen-2-yl-methanone; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 65 ℃; for 1h;
DOI:10.1021/jm00122a020

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 117498-58-5
(4-Amino-3-methylamino-phenyl)-thiophen-2-yl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride, DMF / CHCl₃ / Heating

2: AlCl₃ / CH₂Cl₂ / a) < 10 deg C, 0.5 h, b) room temperature, 2 h

3: 67 percent / dimethylsulfoxide / 8.5 h / 85 °C

4: 1.) H₂, 2.) ethereal HCl / 1.) 10percent Pd/C / methanol / 1 h / 65 °C

With hydrogenchloride; aluminium trichloride; thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm00122a020

Reference yield:

: 67579-92-4
3-methoxy-4-nitrobenzoic acid chloride

: 117498-58-5
(4-Amino-3-methylamino-phenyl)-thiophen-2-yl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: AlCl₃ / CH₂Cl₂ / a) < 10 deg C, 0.5 h, b) room temperature, 2 h

2: 67 percent / dimethylsulfoxide / 8.5 h / 85 °C

3: 1.) H₂, 2.) ethereal HCl / 1.) 10percent Pd/C / methanol / 1 h / 65 °C

With hydrogenchloride; aluminium trichloride; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00122a020