[(2R,4aR,6R,7R,8R,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[(2R,4aR,6R,7R,8R,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-tert-butyl-dimethyl-silane
CAS No.:203925-41-1
Molecular Formula:C₃₀H₄₂O₆Si
Molecular Weight:526.745
Hs Code.:

Synonyms:[(2R,4aR,6R,7R,8R,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-tert-butyl-dimethyl-silane

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Chemical Property of [(2R,4aR,6R,7R,8R,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-tert-butyl-dimethyl-silane

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Technology Process of [(2R,4aR,6R,7R,8R,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-tert-butyl-dimethyl-silane

There total 6 articles about [(2R,4aR,6R,7R,8R,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 194039-09-3
(2R,4aR,6R,7R,8S,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

: 203925-41-1
[(2R,4aR,6R,7R,8R,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: With triethylamine;
DOI:10.1021/ja973287h

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 203925-41-1
[(2R,4aR,6R,7R,8R,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: (+/-)-camphorsulfonic acid, 4 Angstroem molecular sieves / CH₂Cl₂ / 3.5 h / Ambient temperature

2: 93 percent / Et₃N

With 4 A molecular sieve; camphor-10-sulfonic acid; triethylamine; In dichloromethane;
DOI:10.1021/ja973287h

Reference yield:

: 194039-07-1
methyl 3-O-benzyl-α-D-altropyranoside

: 203925-41-1
[(2R,4aR,6R,7R,8R,8aR)-6-Allyl-8-benzyloxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 2.5 h / 70 - 80 °C

2: TMSOTf / acetonitrile / 12 h / Ambient temperature

3: (+/-)-camphorsulfonic acid, 4 Angstroem molecular sieves / CH₂Cl₂ / 3.5 h / Ambient temperature

4: 93 percent / Et₃N

With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; camphor-10-sulfonic acid; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ja973287h