(2S)-N-(3-aminopyridin-4-yl)-2-benzyl-3-(benzylsulfanyl)propanamide

Base Information

• Chemical Name: (2S)-N-(3-aminopyridin-4-yl)-2-benzyl-3-(benzylsulfanyl)propanamide
• CAS No.: 855958-27-9
• Molecular Formula: C₂₂H₂₃N₃OS
• Molecular Weight: 377.51
• Mol file: 855958-27-9.mol

Synonyms:(2S)-N-(3-aminopyridin-4-yl)-2-benzyl-3-(benzylsulfanyl)propanamide

Chemical Property of (2S)-N-(3-aminopyridin-4-yl)-2-benzyl-3-(benzylsulfanyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-N-(3-aminopyridin-4-yl)-2-benzyl-3-(benzylsulfanyl)propanamide

There total 1 articles about (2S)-N-(3-aminopyridin-4-yl)-2-benzyl-3-(benzylsulfanyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

3,4-diaminopyridine (54-96-6) + (2S)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoic acid (95798-38-2) → (2S)-N-(3-aminopyridin-4-yl)-2-benzyl-3-(benzylsulfanyl)propanamide (855958-27-9)

Guidance literature:

(2S)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -20 ℃; for 0.25h;

3,4-diaminopyridine; In tetrahydrofuran; at -20 ℃; for 16h;

DOI:10.1002/hlca.200590051

Reference yield: 93.0%

(2S)-N-(3-aminopyridin-4-yl)-2-benzyl-3-(benzylsulfanyl)propanamide (855958-27-9) → 2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1H-imidazo[4,5-c]pyridine (765951-66-4)

Guidance literature:

With acetic acid; at 65 ℃; for 2.5h;

DOI:10.1002/hlca.200590051

Reference yield:

(2S)-N-(3-aminopyridin-4-yl)-2-benzyl-3-(benzylsulfanyl)propanamide (855958-27-9) → 2-[(1S)-1-benzyl-2-sulfanylethyl]-1H-imidazo[4,5-c]pyridin-5-ium trifluoroacetate

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / AcOH / 2.5 h / 65 °C

2: 10 percent / Na / tetrahydrofuran; liquid ammonia / 0.5 h / -78 °C

With sodium; acetic acid; In tetrahydrofuran; ammonia;

DOI:10.1002/hlca.200590051

upstream raw materials:

3,4-diaminopyridine

(2S)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoic acid

Downstream raw materials:

2-[(1S)-1-benzyl-2-(benzylsulfanyl)ethyl]-1H-imidazo[4,5-c]pyridine