N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid

Base Information

Chemical Name:N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid
CAS No.:797761-60-5
Molecular Formula:C₂₃H₃₁N₃O₁₀
Molecular Weight:509.513
Hs Code.:

N<sup>α</sup>-(3-carboxy-1-oxopropyl)-N<sup>ε</sup>-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid

Synonyms:N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid

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Chemical Property of N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid

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Technology Process of N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid

There total 3 articles about N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 797761-59-2
N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid triallyl ester

: 797761-60-5
N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline; In tetrahydrofuran; for 14h;
DOI:10.1021/ja046426l

Reference yield:

: 1155-64-2,57705-97-2,67178-46-5,25931-47-9
N₆-[(benzyloxy)carbonyl]-L-lysine

: 797761-60-5
N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / Et₃N / dimethylformamide / 8 h / 20 °C

2.1: N-hydroxysuccinimide; dicyclohexylcarbodiimide / dimethylformamide / 0.5 h / 0 °C

2.2: 86 percent / dimethylformamide / 15 h / 20 °C

3.1: 74 percent / (Ph₃P)4Pd; N-methylaniline / tetrahydrofuran / 14 h

With 1-hydroxy-pyrrolidine-2,5-dione; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; dicyclohexyl-carbodiimide; N-methylaniline; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja046426l

Reference yield:

: 797761-58-1
N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysine allyl ester

: 797761-60-5
N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-hydroxysuccinimide; dicyclohexylcarbodiimide / dimethylformamide / 0.5 h / 0 °C

1.2: 86 percent / dimethylformamide / 15 h / 20 °C

2.1: 74 percent / (Ph₃P)4Pd; N-methylaniline / tetrahydrofuran / 14 h

With 1-hydroxy-pyrrolidine-2,5-dione; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dicyclohexyl-carbodiimide; N-methylaniline; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja046426l