2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Base Information

Chemical Name:2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine
CAS No.:1437778-88-5
Molecular Formula:C₂₂H₂₇BrClN₃O₂
Molecular Weight:480.832
Hs Code.:

Synonyms:2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Suppliers and Price of 2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine

There total 14 articles about 2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: cis-tert-butyl 4-[2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate

: 1437778-88-5
2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: triethylamine / ethyl acetate / 4 h / Reflux

3.1: dipotassium hydrogenphosphate; sodium carbonate / water; dimethyl sulfoxide; methanol / 7 h / 21 - 25 °C / pH 7 - 8 / Enzymatic reaction

3.2: 0.5 h / 40 °C / pH Ca_. 14

4.1: palladium on carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

5.1: potassium carbonate / N,N-dimethyl-formamide

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

With hydrogenchloride; dipotassium hydrogenphosphate; di-isopropyl azodicarboxylate; palladium on carbon; hydrogen; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; In methanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 287192-97-6
4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester

: 1437778-88-5
2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C

1.2: 1 h / -78 °C

2.1: quinoline; hydrogen / ethyl acetate / 0.67 h

3.1: C₁₂H₂₃BN₂O₄; diethylzinc / dichloromethane; diethyl ether / 24 h / -20 - 0 °C / Inert atmosphere

4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethyl acetate; ethanol / 0.5 h / 3345.86 Torr

4.2: 0.5 h / 0 °C

5.1: hydrogenchloride / 2 h / 20 °C

6.1: triethylamine / ethyl acetate / 4 h / Reflux

7.1: dipotassium hydrogenphosphate; sodium carbonate / water; dimethyl sulfoxide; methanol / 7 h / 21 - 25 °C / pH 7 - 8 / Enzymatic reaction

7.2: 0.5 h / 40 °C / pH Ca_. 14

8.1: palladium on carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

9.1: potassium carbonate / N,N-dimethyl-formamide

10.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

With quinoline; hydrogenchloride; dipotassium hydrogenphosphate; n-butyllithium; di-isopropyl azodicarboxylate; 10 wt% Pd(OH)2 on carbon; palladium on carbon; C₁₂H₂₃BN₂O₄; hydrogen; diethylzinc; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1192063-78-7
tert-butyl 4-[(4R)-5-(benzyloxy)-4-hydroxypent-1-yn-1-yl]piperidine-1-carboxylate

: 1437778-88-5
2-(4-{(1R,2S)-2-[2-(4-bromo-3-chlorophenoxy)ethyl]cyclopropyl}piperidin-1-yl)-5-(methoxymethyl)pyrimidine

Guidance literature:: Multi-step reaction with 9 steps

1.1: quinoline; hydrogen / ethyl acetate / 0.67 h

2.1: C₁₂H₂₃BN₂O₄; diethylzinc / dichloromethane; diethyl ether / 24 h / -20 - 0 °C / Inert atmosphere

3.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethyl acetate; ethanol / 0.5 h / 3345.86 Torr

3.2: 0.5 h / 0 °C

4.1: hydrogenchloride / 2 h / 20 °C

5.1: triethylamine / ethyl acetate / 4 h / Reflux

6.1: dipotassium hydrogenphosphate; sodium carbonate / water; dimethyl sulfoxide; methanol / 7 h / 21 - 25 °C / pH 7 - 8 / Enzymatic reaction

6.2: 0.5 h / 40 °C / pH Ca_. 14

7.1: palladium on carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

8.1: potassium carbonate / N,N-dimethyl-formamide

9.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

With quinoline; hydrogenchloride; dipotassium hydrogenphosphate; di-isopropyl azodicarboxylate; 10 wt% Pd(OH)2 on carbon; palladium on carbon; C₁₂H₂₃BN₂O₄; hydrogen; diethylzinc; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; In methanol; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;