4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate

Base Information

Chemical Name:4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate
CAS No.:1600565-89-6
Molecular Formula:C₂HF₃O₂*C₂₈H₂₀Cl₂N₄O
Molecular Weight:613.423
Hs Code.:

Synonyms:4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate

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Chemical Property of 4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate

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Technology Process of 4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate

There total 12 articles about 4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1600563-61-8
(4-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)methanol

: 76-05-1
trifluoroacetic acid

: 1600565-89-6
4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate

Guidance literature:: zinc(II) cyanide; (4-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)methanol; With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In N,N-dimethyl acetamide; at 120 ℃; Sealed tube; Inert atmosphere;

trifluoroacetic acid; In N,N-dimethyl acetamide; water; acetonitrile; Sealed tube; Inert atmosphere;

Reference yield:

: 452349-62-1
methyl 5-bromo-2-(2-phenylacetamido)benzoate

: 1600565-89-6
4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane; water / 4 h / -78 - 20 °C

2.1: trichlorophosphate / 3.5 h / 107 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

3.3: Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 120 °C / Sealed tube; Inert atmosphere

4.2: Sealed tube; Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; lithium hexamethyldisilazane; zinc; trichlorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl acetamide; water;

Reference yield:

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

: 1600565-89-6
4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 7.5 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl acetamide / 120 °C / Sealed tube; Inert atmosphere

3.2: Sealed tube; Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; isopropylmagnesium chloride; zinc; In tetrahydrofuran; hexane; N,N-dimethyl acetamide;