ethyl (R)-3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionate

Base Information

• Chemical Name: ethyl (R)-3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionate
• CAS No.: 710327-12-1
• Molecular Formula: C₂₀H₂₄O₄
• Molecular Weight: 328.408
• Mol file: 710327-12-1.mol

Synonyms:ethyl (R)-3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionate

Chemical Property of ethyl (R)-3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (R)-3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionate

There total 4 articles about ethyl (R)-3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl (R)-3-(4-benzyloxyphenyl)-2-(4-isopropylphenoxy)propionate (710327-11-0) → ethyl (R)-3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionate (710327-12-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃;

DOI:10.1016/j.bmc.2004.01.048

Reference yield:

ethyl 2-hydroxy-3-(4-hydroxyphenyl)propionate (62517-34-4) → ethyl (R)-3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionate (710327-12-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / K₂CO₃ / dimethylformamide / 4 h / 60 °C

2: 56 percent / triphenylphosphine; diethyl azodicarboxylate / toluene / 20 °C

3: NaOH / ethanol / 20 °C

4: 99 percent / H₂SO₄ / 20 °C

5: 99 percent / H₂ / Pd/C / ethanol / 50 °C

With sodium hydroxide; sulfuric acid; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; toluene; 2: Mitsunobu reaction;

DOI:10.1016/j.bmc.2004.01.048

Reference yield:

ethyl 3-(4-benzyloxyphenyl)lactate (141109-83-3) → ethyl (R)-3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionate (710327-12-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 56 percent / triphenylphosphine; diethyl azodicarboxylate / toluene / 20 °C

2: NaOH / ethanol / 20 °C

3: 99 percent / H₂SO₄ / 20 °C

4: 99 percent / H₂ / Pd/C / ethanol / 50 °C

With sodium hydroxide; sulfuric acid; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; toluene; 1: Mitsunobu reaction;

DOI:10.1016/j.bmc.2004.01.048

upstream raw materials:

ethyl (R)-3-(4-benzyloxyphenyl)-2-(4-isopropylphenoxy)propionate

ethyl 2-hydroxy-3-(4-hydroxyphenyl)propionate

ethyl 3-(4-benzyloxyphenyl)lactate

(R)-3-(4-benzyloxyphenyl)-2-(4-isopropylphenoxy)propionic acid

Downstream raw materials:

ethyl (R)-3-[4-(2-tert-butoxycarbonylaminoethoxy)phenyl]-2-(4-isopropylphenoxy)propionate

ethyl (R)-2-(4-isopropylphenoxy)-3-[4-[2-[(4-(pyridin-2-yl)benzoyl)amino]ethoxy]phenyl]propionate