1-(Benzyloxy)-4-(bromomethyl)benzene

Base Information

• Chemical Name: 1-(Benzyloxy)-4-(bromomethyl)benzene
• CAS No.: 5544-60-5
• Molecular Formula: C14H13BrO
• Molecular Weight: 277.161
• Hs Code.: 2909309090
• European Community (EC) Number: 827-636-9
• DSSTox Substance ID: DTXSID90440850
• Nikkaji Number: J1.412.325C
• Wikidata: Q72441786
• Mol file: 5544-60-5.mol

Synonyms:5544-60-5;1-(benzyloxy)-4-(bromomethyl)benzene;4-Benzyloxybenzyl bromide;4-Benzyloxybenzylbromide;1-(bromomethyl)-4-phenylmethoxybenzene;Benzene, 1-(bromomethyl)-4-(phenylmethoxy)-;4-(Benzyloxy)benzyl bromide;1-benzyloxy-4-bromomethylbenzene;1-(benzyloxy)-4-(bromomethyl) benzene;p-Benzyloxybenzyl bromide;4-benzyloxy benzyl bromide;SCHEMBL282581;DTXSID90440850;KHZAFUOYPXXJKO-UHFFFAOYSA-N;benzyl 4-(bromomethyl)phenyl ether;MFCD07368336;AKOS009307151;AB91104;DS-16449;FT-0602762;EN300-66239;A830650;A1-01525

Chemical Property of 1-(Benzyloxy)-4-(bromomethyl)benzene

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 83-85 °C
• Refractive Index: 1.604
• Boiling Point: 366.024 ºC at 760 mmHg
• Flash Point: 143 ºC
• PSA: 9.23000
• Density: 1.361 g/cm³
• LogP: 4.16050
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: Dichloromethane
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 276.01498
• Heavy Atom Count: 16
• Complexity: 181

Purity/Quality:

98%min ^*data from raw suppliers

4-BenzyloxybenzylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)CBr
• Uses: 4-BENZYLOXYBENZYL BROMIDE is a useful reactant in the synthesis of many antibacterial drugs. Ethyl 4-benzyloxybenzoate analogue with hypolipidemic activity.

Technology Process of 1-(Benzyloxy)-4-(bromomethyl)benzene

There total 20 articles about 1-(Benzyloxy)-4-(bromomethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzyloxybenzyl alcohol (836-43-1) → 4-(benzyloxy)benzyl bromide (5544-60-5)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1002/1522-2675(200210)85:10<3422::AID-HLCA3422>3.0.CO;2-N

Reference yield: 89.0%

1-(benzyloxy)-4-((methoxymethoxy)methyl) benzene (392717-83-8) → 4-(benzyloxy)benzyl bromide (5544-60-5)

Guidance literature:

With phosphotungstic acid; tetrabutylammomium bromide; at 130 - 142 ℃; for 0.025h; chemoselective reaction; Microwave irradiation; Ionic liquid;

DOI:10.1016/j.crci.2010.03.015

Reference yield: 82.0%

1-(benzyloxy)-4-((ethoxymethoxy)methyl) benzene (1058648-76-2) → 4-(benzyloxy)benzyl bromide (5544-60-5)

Guidance literature:

With tetrabutylammomium bromide; 1-(n-butyl)-3-methylimidazolium tetrachloroindate; at 135 - 140 ℃; for 0.075h; chemoselective reaction; Microwave irradiation; Neat (no solvent);

DOI:10.1016/j.tetlet.2010.04.056

upstream raw materials:

4-benzyloxybenzyl alcohol

Ethyl 4-hydroxybenzoate

ethyl 4-(benzyloxy)benzoate

benzyl bromide

Downstream raw materials:

methyl 2-methoxy-3-(4-benzyloxy)phenylpropionate

3-(phenylseleno)-4-<(4-phenylmethoxy)phenyl>butene

1-(4-(benzyloxy)benzyl)-1-cyano-5-methoxy-1,2,3,4-tetrahydronaphthalene

1-<4-(benzyloxy)benzyl>-2-(4-tert-butylbenzoyl)-8-methoxy-1,2,3,4-tetrahydroisoquinoline