(E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-ol

Base Information

Chemical Name:(E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-ol
CAS No.:1416164-00-5
Molecular Formula:C₂₆H₂₁Cl₂F₂N₃O₃
Molecular Weight:532.374
Hs Code.:

Synonyms:(E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-ol

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Chemical Property of (E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-ol

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Technology Process of (E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-ol

There total 5 articles about (E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

: 1416163-69-3
(E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-one

: 1416164-00-5
(E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-ol

Guidance literature:: With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 86386-76-7,123632-22-4,141113-42-0,150024-48-9
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

: 1416164-00-5
(E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetrabutylammomium bromide / ethyl acetate / 12 h / Reflux; Inert atmosphere

2: sodium tetrahydroborate; methanol / 3 h / 0 - 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; tetrabutylammomium bromide; potassium carbonate; In ethyl acetate;

Reference yield:

: 99-93-4
4-Hydroxyacetophenone

: 1416164-00-5
(E)-3-(2,4-dichlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrabutylammomium bromide / ethyl acetate / 12 h / Inert atmosphere; Reflux

2: sodium hydroxide / water; methanol / 18 h / 20 °C

3: sodium tetrahydroborate; methanol / 3 h / 0 - 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; tetrabutylammomium bromide; potassium carbonate; sodium hydroxide; In methanol; water; ethyl acetate;