1--2-(2'-fluorobenzoyl)naphthalene

Base Information

Chemical Name:1--2-(2'-fluorobenzoyl)naphthalene
CAS No.:154848-99-4
Molecular Formula:C₁₉H₁₃BrFNO₂
Molecular Weight:386.22
Hs Code.:

1-<N-(bromoacetyl)amino>-2-(2'-fluorobenzoyl)naphthalene

Synonyms:1--2-(2'-fluorobenzoyl)naphthalene

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Chemical Property of 1--2-(2'-fluorobenzoyl)naphthalene

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Technology Process of 1--2-(2'-fluorobenzoyl)naphthalene

There total 6 articles about 1--2-(2'-fluorobenzoyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 598-21-0
2-Bromoacetyl bromide

: 153684-36-7
1-amino-2-(2'-fluorobenzoyl)naphthalene

: 154848-99-4
1--2-(2'-fluorobenzoyl)naphthalene

Guidance literature:: With sodium hydrogencarbonate; In chloroform; at 0 ℃; for 0.5h;
DOI:10.1021/jm00032a007

Reference yield:

: 1072-85-1
o-fluorobromobenzene

: 154848-99-4
1--2-(2'-fluorobenzoyl)naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 20 min

2: 95 percent / 48percent aq. HBr, glacial acetic acid / 10 h / Heating

3: 92 percent / NaHCO₃ / CHCl₃ / 0.5 h / 0 °C

With n-butyllithium; hydrogen bromide; sodium hydrogencarbonate; acetic acid; In chloroform;
DOI:10.1021/jm00032a007

Reference yield:

: 3100-67-2
1-amino-2-naphthalenecarbonitrile

: 154848-99-4
1--2-(2'-fluorobenzoyl)naphthalene

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / 20percent aq. NaOH / ethanol / 10 h / Heating

2: 91 percent / 3 h / 170 °C

3: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 20 min

4: 95 percent / 48percent aq. HBr, glacial acetic acid / 10 h / Heating

5: 92 percent / NaHCO₃ / CHCl₃ / 0.5 h / 0 °C

With sodium hydroxide; n-butyllithium; hydrogen bromide; sodium hydrogencarbonate; acetic acid; In ethanol; chloroform;
DOI:10.1021/jm00032a007