N-benzylimino-bis(acetyl(1-(3'-aminopropyl)-3-benzyloxy-2-methyl-4-pyridinone))

Base Information

• Chemical Name: N-benzylimino-bis(acetyl(1-(3'-aminopropyl)-3-benzyloxy-2-methyl-4-pyridinone))
• CAS No.: 813432-02-9
• Molecular Formula: C₄₃H₄₉N₅O₆
• Molecular Weight: 731.892
• Mol file: 813432-02-9.mol

Synonyms:N-benzylimino-bis(acetyl(1-(3'-aminopropyl)-3-benzyloxy-2-methyl-4-pyridinone))

Chemical Property of N-benzylimino-bis(acetyl(1-(3'-aminopropyl)-3-benzyloxy-2-methyl-4-pyridinone))

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzylimino-bis(acetyl(1-(3'-aminopropyl)-3-benzyloxy-2-methyl-4-pyridinone))

There total 4 articles about N-benzylimino-bis(acetyl(1-(3'-aminopropyl)-3-benzyloxy-2-methyl-4-pyridinone)) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N-benzyliminodiacetic acid (3987-53-9) + 1-(3-aminopropyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one hydrochloride salt → N-benzylimino-bis(acetyl(1-(3'-aminopropyl)-3-benzyloxy-2-methyl-4-pyridinone)) (813432-02-9)

Guidance literature:

1-(3-aminopropyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one hydrochloride salt; With potassium hydroxide; In methanol; at 0 ℃; for 0.25h;

N-benzyliminodiacetic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 3.5h; Further stages.;

DOI:10.1039/b409357g

Reference yield:

benzyl chloride (100-44-7) → N-benzylimino-bis(acetyl(1-(3'-aminopropyl)-3-benzyloxy-2-methyl-4-pyridinone)) (813432-02-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; water / 6 h / Heating

2.1: sodium hydroxide / ethanol; water / 24 h / 70 - 75 °C

3.1: potassium hydroxide / methanol / 0.25 h / 0 °C

3.2: ethyl chloroformate; NMM / 13 / 3.5 h / 0 °C

With potassium hydroxide; sodium hydroxide; In methanol; ethanol; water;

DOI:10.1039/b409357g

Reference yield:

Maltol (118-71-8) → N-benzylimino-bis(acetyl(1-(3'-aminopropyl)-3-benzyloxy-2-methyl-4-pyridinone)) (813432-02-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; water / 6 h / Heating

2.1: sodium hydroxide / ethanol; water / 24 h / 70 - 75 °C

3.1: potassium hydroxide / methanol / 0.25 h / 0 °C

3.2: ethyl chloroformate; NMM / 13 / 3.5 h / 0 °C

With potassium hydroxide; sodium hydroxide; In methanol; ethanol; water;

DOI:10.1039/b409357g

upstream raw materials:

N-benzyliminodiacetic acid

Maltol

3-O-benzylmaltol

benzyl chloride