N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester

Base Information

Chemical Name:N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester
CAS No.:308279-70-1
Molecular Formula:C₂₆H₄₁N₃O₅
Molecular Weight:475.629
Hs Code.:

Synonyms:N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester

Chemical Property:

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Technology Process of N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester

There total 9 articles about N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 308279-69-8
(S)-3-Benzyloxy-2-{(2S,3R)-2-[(S)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester

: 308279-70-1
N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1021/ja002547j

Reference yield:

: 1509-34-8,959215-79-3,18875-42-8
D-allo-isoleucine

: 308279-70-1
N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / aq. NaOH / dioxane / 2.5 h / 20 °C

2: 97 percent / PyBOP; Et₃N / CH₂Cl₂ / 8.5 h / 0 - 20 °C

3: 95 percent / aq. HCl / ethyl acetate / 1 h / 20 °C

4: 99 percent / PyBOP; Et₃N / CH₂Cl₂ / 7 h / 0 - 20 °C

5: aq. HCl / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/ja002547j

Reference yield:

: 13139-16-7,35264-07-4,55721-65-8,55780-90-0,116194-21-9
Boc-L-aIle-OH

: 308279-70-1
N-methyl-L-leucine-L-allo-isoleucine-O-benzyl-L-serine allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / PyBOP; Et₃N / CH₂Cl₂ / 8.5 h / 0 - 20 °C

2: 95 percent / aq. HCl / ethyl acetate / 1 h / 20 °C

3: 99 percent / PyBOP; Et₃N / CH₂Cl₂ / 7 h / 0 - 20 °C

4: aq. HCl / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1021/ja002547j