methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate

Base Information

Chemical Name:methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate
CAS No.:1441379-70-9
Molecular Formula:C₂₂H₂₀O₇
Molecular Weight:396.397
Hs Code.:

Synonyms:methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate

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Chemical Property of methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate

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Technology Process of methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate

There total 7 articles about methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1404435-51-3
6-iodo-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 474677-87-7
methyl 2-(3-ethynylphenoxy)acetate

: 1441379-70-9
methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 40 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1021/jm400248c

Reference yield:

: 89-86-1
4-hydroxysalicylic acid

: 1441379-70-9
methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: Iodine monochloride; acetic acid / 4 h / 20 °C

2: trifluoroacetic acid / acetone / 24 h / 20 °C

3: potassium carbonate / dimethyl sulfoxide / 4 h / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 40 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Iodine monochloride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; 4: |Sonogashira Cross-Coupling;
DOI:10.1021/jm400248c

Reference yield:

: 856106-63-3
2,4-dihydroxy-5-iodobenzoic acid

: 1441379-70-9
methyl 2-(3-((7-methoxy-2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-6-yl)ethynyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / acetone / 24 h / 20 °C

2: potassium carbonate / dimethyl sulfoxide / 4 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 40 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; trifluoroacetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/jm400248c