2-butyl-5-(4-fluorophenylthio-methyl)-4-hydroxy-4-methyl-1,1-dioxo-isothiazolidine

Base Information

Chemical Name:2-butyl-5-(4-fluorophenylthio-methyl)-4-hydroxy-4-methyl-1,1-dioxo-isothiazolidine
CAS No.:1423166-12-4
Molecular Formula:C₁₅H₂₂FNO₃S₂
Molecular Weight:347.475
Hs Code.:

Synonyms:2-butyl-5-(4-fluorophenylthio-methyl)-4-hydroxy-4-methyl-1,1-dioxo-isothiazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-butyl-5-(4-fluorophenylthio-methyl)-4-hydroxy-4-methyl-1,1-dioxo-isothiazolidine

Chemical Property:

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Technology Process of 2-butyl-5-(4-fluorophenylthio-methyl)-4-hydroxy-4-methyl-1,1-dioxo-isothiazolidine

There total 6 articles about 2-butyl-5-(4-fluorophenylthio-methyl)-4-hydroxy-4-methyl-1,1-dioxo-isothiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%

: 371-42-6
4-Fluorothiophenol

: 1423165-98-3
2-butyl-4-methyl-5-methylene-1,1-dioxo-isothiazolidin-4-ol

: 1423166-12-4
2-butyl-5-(4-fluorophenylthio-methyl)-4-hydroxy-4-methyl-1,1-dioxo-isothiazolidine

Guidance literature:: In ethanol; water; Inert atmosphere;
DOI:10.1016/j.tet.2012.12.083

Reference yield:

: 25250-77-5
2-(N-n-butylamino)-1-methylethanol

: 1423166-12-4
2-butyl-5-(4-fluorophenylthio-methyl)-4-hydroxy-4-methyl-1,1-dioxo-isothiazolidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; dmap / dichloromethane / 36 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

3.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: Jones reagent / acetone / 5 h / 0 - 20 °C / Inert atmosphere

4.2: 0.08 h / 20 °C / Inert atmosphere

5.1: 1,4-diaza-bicyclo[2.2.2]octane / water; 1,4-dioxane / 20 °C

6.1: water; ethanol / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; dmap; Jones reagent; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetone; 4.1: |Jones Oxidation / 5.1: |Baylis-Hillman Reaction;
DOI:10.1016/j.tet.2012.12.083

Reference yield:

: 1423165-66-5
C₁₅H₃₃NO₃SSi

: 1423166-12-4
2-butyl-5-(4-fluorophenylthio-methyl)-4-hydroxy-4-methyl-1,1-dioxo-isothiazolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: Jones reagent / acetone / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 0.08 h / 20 °C / Inert atmosphere

3.1: 1,4-diaza-bicyclo[2.2.2]octane / water; 1,4-dioxane / 20 °C

4.1: water; ethanol / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; Jones reagent; water; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetone; 2.1: |Jones Oxidation / 3.1: |Baylis-Hillman Reaction;
DOI:10.1016/j.tet.2012.12.083