1-{[(E,3S,4S)-4-methyl-1-nitrohex-1-en-3-yloxy]methyl}-3,5-difluorobenzene

Base Information

Chemical Name:1-{[(E,3S,4S)-4-methyl-1-nitrohex-1-en-3-yloxy]methyl}-3,5-difluorobenzene
CAS No.:858366-98-0
Molecular Formula:C₁₄H₁₇F₂NO₃
Molecular Weight:285.291
Hs Code.:

Synonyms:1-{[(E,3S,4S)-4-methyl-1-nitrohex-1-en-3-yloxy]methyl}-3,5-difluorobenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-{[(E,3S,4S)-4-methyl-1-nitrohex-1-en-3-yloxy]methyl}-3,5-difluorobenzene

Chemical Property:

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Technology Process of 1-{[(E,3S,4S)-4-methyl-1-nitrohex-1-en-3-yloxy]methyl}-3,5-difluorobenzene

There total 7 articles about 1-{[(E,3S,4S)-4-methyl-1-nitrohex-1-en-3-yloxy]methyl}-3,5-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 858366-92-4
(3S,4S)-3-(3,5-Difluoro-benzyloxy)-4-methyl-1-nitro-hexan-2-ol

: 858366-98-0
1-{[(E,3S,4S)-4-methyl-1-nitrohex-1-en-3-yloxy]methyl}-3,5-difluorobenzene

Guidance literature:: With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -70 - 20 ℃;
DOI:10.1002/anie.200462497

Reference yield:

: 858366-82-2
(2S,3S)-2-(3,5-difluorobenzyloxy)-3-methylpentanal

: 858366-98-0
1-{[(E,3S,4S)-4-methyl-1-nitrohex-1-en-3-yloxy]methyl}-3,5-difluorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 16 h / 20 °C

2: methanesulfonyl chloride; ethyldiisopropylamine / CH₂Cl₂ / -70 - 20 °C

With methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Henry reaction;
DOI:10.1002/anie.200462497

Reference yield:

: 862666-05-5
(2S,3S)-2-(3,5-Difluoro-benzyloxy)-3-methyl-pentan-1-ol

: 858366-98-0
1-{[(E,3S,4S)-4-methyl-1-nitrohex-1-en-3-yloxy]methyl}-3,5-difluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 5 h / -70 - -60 °C

2: triethylamine / 16 h / 20 °C

3: methanesulfonyl chloride; ethyldiisopropylamine / CH₂Cl₂ / -70 - 20 °C

With oxalyl dichloride; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; 2: Henry reaction;
DOI:10.1002/anie.200462497