tert-butyl (2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate
CAS No.:1261071-88-8
Molecular Formula:C₂₆H₂₆BrN₅O₂
Molecular Weight:520.429
Hs Code.:

Synonyms:tert-butyl (2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

There total 12 articles about tert-butyl (2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 55687-02-0
6-bromo-2-chloro-quinoxaline

: 1007882-12-3
(S)-2-{4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1261071-88-8
C₂₆H₂₆BrN₅O₂

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,2-dimethoxyethane; at 20 ℃;
DOI:10.1002/cmdc.201400045

Reference yield:

: 55687-02-0
6-bromo-2-chloro-quinoxaline

: 1007882-12-3
(S)-tert-butyl 2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261071-88-8
tert-butyl (2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 30 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 55687-34-8
6-bromoquinoxalin-2(1H)-one

: 1261071-88-8
tert-butyl (2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 1.5 h / 120 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 30 °C / Inert atmosphere

With sodium carbonate; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;