4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide

Base Information

• Chemical Name: 4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide
• CAS No.: 1350918-52-3
• Molecular Formula: C₃₀H₄₀N₆O₃Si
• Molecular Weight: 560.772
• Mol file: 1350918-52-3.mol

Synonyms:4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide

Chemical Property of 4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide

There total 5 articles about 4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(2'-aminophenoxy)-1-(N,N-dimethylamino)-ethane (1202-00-2) + lithium 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate (1350917-95-1) → 4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide (1350918-52-3)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide (1350918-52-3)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

4: water; lithium hydroxide / 1,4-dioxane / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 50 °C

With 4-methyl-morpholine; N-Bromosuccinimide; water; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

ethyl 4-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazole-2-carboxylate (954125-17-8) → 4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide (1350918-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

2: water; lithium hydroxide / 1,4-dioxane / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 50 °C

With 4-methyl-morpholine; water; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

(2-trimethylethylsilylethoxy)methyl chloride

2-(2'-aminophenoxy)-1-(N,N-dimethylamino)-ethane

lithium 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

ethyl 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

Downstream raw materials:

N-(2-(2-(dimethylamino)ethoxy)phenyl)-4-(1-(phenylmetyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide