(E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoic acid

Base Information

Chemical Name:(E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoic acid
CAS No.:926296-70-0
Molecular Formula:C₁₇H₁₆ClF₃N₂O₄
Molecular Weight:404.773
Hs Code.:

Synonyms:(E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoic acid

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Chemical Property of (E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoic acid

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Technology Process of (E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoic acid

There total 7 articles about (E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 926299-37-8
ethyl (E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoate

: 926296-70-0
(E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoic acid

Guidance literature:: ethyl (E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoate; With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmc.2011.12.008

Reference yield:

: 1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(methoxymethoxy)-1H-pyrazole-5-carboxylic acid

: 926296-70-0
(E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -78 - 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 0 - 20 °C

4.1: hydrogenchloride / ethanol; water / Reflux

5.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 20 °C

6.1: sodium hydroxide / tetrahydrofuran; methanol / 50 °C

With hydrogenchloride; tributylphosphine; sodium hydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; 3.2: Horner-Wadsworth-Emmons reaction / 5.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.12.008

Reference yield:

: 926296-30-2
1-[2-chloro-4-(trifluoromethyl)benzyl]-N-methoxy-3-(methoxymethoxy)-N-methyl-1H-pyrazole-5-carboxamide

: 926296-70-0
(E)-3-[1-[2-chloro-4-(trifluoromethyl)benzyl]-3-(2-methoxyethoxy)-1H-pyrazol-5-yl]propenoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -78 - 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / ethanol; water / Reflux

4.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 20 °C

5.1: sodium hydroxide / tetrahydrofuran; methanol / 50 °C

With hydrogenchloride; tributylphosphine; sodium hydride; diisobutylaluminium hydride; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; 2.2: Horner-Wadsworth-Emmons reaction / 4.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.12.008