2-{2-[bis-(4-hydroxy-phenyl)-methyl]-phenyl}-acetamide

Base Information

• Chemical Name: 2-{2-[bis-(4-hydroxy-phenyl)-methyl]-phenyl}-acetamide
• CAS No.: 530135-40-1
• Molecular Formula: C₂₁H₁₉NO₃
• Molecular Weight: 333.387
• Mol file: 530135-40-1.mol

Synonyms:2-{2-[bis-(4-hydroxy-phenyl)-methyl]-phenyl}-acetamide

Chemical Property of 2-{2-[bis-(4-hydroxy-phenyl)-methyl]-phenyl}-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-[bis-(4-hydroxy-phenyl)-methyl]-phenyl}-acetamide

There total 6 articles about 2-{2-[bis-(4-hydroxy-phenyl)-methyl]-phenyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-{2-[bis-(4-benzyloxy-phenyl)-methyl]-phenyl}-acetamide (530135-39-8) → 2-{2-[bis-(4-hydroxy-phenyl)-methyl]-phenyl}-acetamide (530135-40-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 2280 Torr;

DOI:10.1016/S0968-0896(02)00318-8

Reference yield:

methyl 2-(4,4'-dihydroxybenzhydryl)benzoate (62218-29-5) → 2-{2-[bis-(4-hydroxy-phenyl)-methyl]-phenyl}-acetamide (530135-40-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 85 percent / K₂CO₃ / acetone / 18 h / Heating

2: 86 percent / LiAlH₄ / diethyl ether / 1.5 h / 30 °C

3: 86 percent / PBr₃ / CH₂Cl₂ / 2 h / 20 °C

4: 84 percent / dimethylsulfoxide / 1.5 h / 70 °C

5: 58 percent / aq. NaOH / 12 h / Heating

6: 77 percent / H₂ / Pd/C / methanol / 3 h / 2280 Torr

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; phosphorus tribromide; potassium carbonate; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; acetone;

DOI:10.1016/S0968-0896(02)00318-8

Reference yield:

2-(4,4'-dibenzyloxybenzhydryl)benzylalcohol (96673-63-1) → 2-{2-[bis-(4-hydroxy-phenyl)-methyl]-phenyl}-acetamide (530135-40-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / PBr₃ / CH₂Cl₂ / 2 h / 20 °C

2: 84 percent / dimethylsulfoxide / 1.5 h / 70 °C

3: 58 percent / aq. NaOH / 12 h / Heating

4: 77 percent / H₂ / Pd/C / methanol / 3 h / 2280 Torr

With sodium hydroxide; hydrogen; phosphorus tribromide; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/S0968-0896(02)00318-8

upstream raw materials:

2-{2-[bis-(4-benzyloxy-phenyl)-methyl]-phenyl}-acetamide

methyl 2-(4,4'-dihydroxybenzhydryl)benzoate

methyl 2-(4,4'-dibenzyloxybenzhydryl)benzoate

2-(4,4'-dibenzyloxybenzhydryl)benzylalcohol

Downstream raw materials:

4.4'-Dihydroxy-triphenylmethan-2'-essigsaeure