bis[2-(trimethylsilyl)ethyl] 1,4-benzenedicarboxylate

Base Information

• Chemical Name: bis[2-(trimethylsilyl)ethyl] 1,4-benzenedicarboxylate
• CAS No.: 335248-33-4
• Molecular Formula: C₁₈H₃₀O₄Si₂
• Molecular Weight: 366.605
• Mol file: 335248-33-4.mol

Synonyms:bis[2-(trimethylsilyl)ethyl] 1,4-benzenedicarboxylate

Chemical Property of bis[2-(trimethylsilyl)ethyl] 1,4-benzenedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis[2-(trimethylsilyl)ethyl] 1,4-benzenedicarboxylate

There total 1 articles about bis[2-(trimethylsilyl)ethyl] 1,4-benzenedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + terephthaloyl chloride (100-20-9) → bis[2-(trimethylsilyl)ethyl] 1,4-benzenedicarboxylate (335248-33-4)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1021/jo001167d

Reference yield: 80.0%

bis[2-(trimethylsilyl)ethyl] 1,4-benzenedicarboxylate (335248-33-4) → hydrogen 2-(trimethylsilyl)ethyl 1,4-benzenedicarboxylate (335248-35-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo001167d

Reference yield:

bis[2-(trimethylsilyl)ethyl] 1,4-benzenedicarboxylate (335248-33-4) → (1R,3S,4R,6S,7R,9R,10S,12R,13S,15R)-15-[(t-butyldimethylsilyloxy)methyl]-1-quinquecyclopropanemethyl 2-(trimethylsilyl)ethyl 1,4-benzenedicarboxylate (335248-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / TBAF / tetrahydrofuran / 20 °C

2: 93 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

With dmap; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; 2: Steglich esterification;

DOI:10.1021/jo001167d

upstream raw materials:

2-(Trimethylsilyl)ethanol

terephthaloyl chloride

Downstream raw materials:

hydrogen 2-(trimethylsilyl)ethyl 1,4-benzenedicarboxylate

(1R,3S,4R,6S,7R,9R,10S,12R,13S,15R)-15-[(t-butyldimethylsilyloxy)methyl]-1-quinquecyclopropanemethyl 2-(trimethylsilyl)ethyl 1,4-benzenedicarboxylate