(2S)-1-(3,4-methylenedioxyphenyl)-2,3-(N-triphenylmethylepimino)-1-propanol

Base Information

Chemical Name:(2S)-1-(3,4-methylenedioxyphenyl)-2,3-(N-triphenylmethylepimino)-1-propanol
CAS No.:236742-78-2
Molecular Formula:C₂₉H₂₅NO₃
Molecular Weight:435.522
Hs Code.:

Synonyms:(2S)-1-(3,4-methylenedioxyphenyl)-2,3-(N-triphenylmethylepimino)-1-propanol

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Chemical Property of (2S)-1-(3,4-methylenedioxyphenyl)-2,3-(N-triphenylmethylepimino)-1-propanol

Chemical Property:

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Technology Process of (2S)-1-(3,4-methylenedioxyphenyl)-2,3-(N-triphenylmethylepimino)-1-propanol

There total 2 articles about (2S)-1-(3,4-methylenedioxyphenyl)-2,3-(N-triphenylmethylepimino)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2635-13-4
1,2-(methylenedioxy)-4-bromobenzene

: 152706-54-2
1-triphenylmethyl-2-aziridinecarboxaldehyde

: 236742-78-2
(2S)-1-(3,4-methylenedioxyphenyl)-2,3-(N-triphenylmethylepimino)-1-propanol

Guidance literature:: 1,2-(methylenedioxy)-4-bromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

1-triphenylmethyl-2-aziridinecarboxaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1016/S0040-4020(99)00345-2

Reference yield:

: 152706-23-5
(S)-N-triphenylmethyl-aziridinylmethanol

: 236742-78-2
(2S)-1-(3,4-methylenedioxyphenyl)-2,3-(N-triphenylmethylepimino)-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 3.8 h / -65 - 20 °C

2.1: nBuLi / tetrahydrofuran; hexane / 1.5 h / -78 °C

2.2: 64 percent / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1.1: Swern oxidation / 2.1: Metallation / 2.2: Grignard reaction;
DOI:10.1016/S0040-4020(99)00345-2

Reference yield:

: 236742-78-2
(2S)-1-(3,4-methylenedioxyphenyl)-2,3-(N-triphenylmethylepimino)-1-propanol

: 3,4-methylenedioxyphenyl (1S)-N-triphenylmethylaziridinyl ketone

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -65 - 20 ℃; for 3.8h;
DOI:10.1016/S0040-4020(99)00345-2