1-(benzo[d][1,3]dioxol-5-yl)-N-(6-methyl-3'-(2H-tetrazol-5-yl)biphenyl-3-yl)cyclopropanecarboxamide

Base Information

• Chemical Name: 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-methyl-3'-(2H-tetrazol-5-yl)biphenyl-3-yl)cyclopropanecarboxamide
• CAS No.: 945239-00-9
• Molecular Formula: C₂₅H₂₁N₅O₃
• Molecular Weight: 439.473
• Mol file: 945239-00-9.mol

Synonyms:1-(benzo[d][1,3]dioxol-5-yl)-N-(6-methyl-3'-(2H-tetrazol-5-yl)biphenyl-3-yl)cyclopropanecarboxamide

Chemical Property of 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-methyl-3'-(2H-tetrazol-5-yl)biphenyl-3-yl)cyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-methyl-3'-(2H-tetrazol-5-yl)biphenyl-3-yl)cyclopropanecarboxamide

There total 6 articles about 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-methyl-3'-(2H-tetrazol-5-yl)biphenyl-3-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3-bromo-phenyl)-1H-tetrazole (3440-99-1) + 1-(benzo[d][1,3]dioxol-5-yl)-N-(4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxamide (945244-23-5) → 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-methyl-3'-(2H-tetrazol-5-yl)biphenyl-3-yl)cyclopropanecarboxamide (945239-00-9)

Guidance literature:

With potassium carbonate; Pd-FibreCat 1007; In ethanol; at 110 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

1-(benzo[d][1,3]dioxol-5-yl)-N-(3-bromo-4-methylphenyl)cyclopropanecarboxamide (945244-49-5) → 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-methyl-3'-(2H-tetrazol-5-yl)biphenyl-3-yl)cyclopropanecarboxamide (945239-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate / Pd(dppf)Cl₂ / dichloromethane; N,N-dimethyl-formamide

2: potassium carbonate / ethanol

With potassium acetate; potassium carbonate; Pd(dppf)Cl₂; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

3,4-methylenedioxyphenylacetonitrile (4439-02-5) → 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-methyl-3'-(2H-tetrazol-5-yl)biphenyl-3-yl)cyclopropanecarboxamide (945239-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; sodium hydroxide; sodium chloride; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane

2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / methanol; ethyl acetate; N,N-dimethyl-formamide

3: potassium carbonate / ethanol

With hydrogenchloride; sodium hydroxide; sodium chloride; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

5-(3-bromo-phenyl)-1H-tetrazole

1-(benzo[d][1,3]dioxol-5-yl)-N-(4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxamide

piperonylonitrile

3,4-methylenedioxyphenylacetonitrile