2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Base Information

• Chemical Name: 2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester
• CAS No.: 141062-45-5
• Molecular Formula: C₂₅H₄₀N₂O₄
• Molecular Weight: 432.604
• Mol file: 141062-45-5.mol

Synonyms:2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Chemical Property of 2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

There total 6 articles about 2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-1-amino-2-(methoxymethyl)pyrrolidine (59983-39-0,187035-29-6) + 2-Oxo-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester (141062-26-2) → 2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester (141062-45-5)

Guidance literature:

Reference yield: 96.0%

(R)-1-Amino-2-(methoxymethyl)pyrrolidine (72748-99-3,187035-29-6) + 2-Oxo-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester (141062-26-2) → 2-[(E)-(R)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester (141062-45-5)

Guidance literature:

Reference yield:

2,6-Di-t-butyl-4-methoxyphenol (489-01-0) → 2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester (141062-45-5)

Guidance literature:

Multi-step reaction with 3 steps

1: nBuLi / tetrahydrofuran / 0 °C

2: 98 percent / diethyl ether / -78 °C

3: 96 percent

With n-butyllithium; In tetrahydrofuran; diethyl ether;

upstream raw materials:

(S)-1-amino-2-(methoxymethyl)pyrrolidine

2-Oxo-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

2,6-Di-t-butyl-4-methoxyphenol

2,6-di-tert-butyl-4-methoxyphenyl ethyl oxalate

Downstream raw materials:

(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-3,4-dimethyl-pentanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

(R)-4-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

(S)-5-Benzyloxy-2-[(E)-(S)-2-methoxymethyl-pyrrolidin-1-ylimino]-3-methyl-pentanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-3,6-dimethyl-hept-5-enoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester