3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide

Base Information

Chemical Name:3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide
CAS No.:1621421-64-4
Molecular Formula:C₂₄H₂₉N₃O₅
Molecular Weight:439.511
Hs Code.:

Synonyms:3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide

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Chemical Property of 3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide

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Technology Process of 3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide

There total 6 articles about 3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.4%

: 914389-37-0,914389-38-1
(+/-)-2-(4-methoxyphenyl)-2,5-diazaspiro[3,4]octan-1-one

: 1621422-14-7
C₁₁H₁₃NO₃

: 1621421-64-4
3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide

Guidance literature:: With triethylamine; In ethanol; for 0.166667h; Heating; Microwave irradiation;

Reference yield:

: 59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester

: 1621421-64-4
3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -45 °C

1.2: 1 h / -45 °C

2.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C

3.1: lithium bromide; sodium tetrahydroborate / methanol / 12 h

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / Sonication

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

6.1: triethylamine / ethanol / 0.17 h / Heating; Microwave irradiation

With 4-methyl-morpholine; sodium tetrahydroborate; di-isopropyl azodicarboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium bromide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1621421-78-0
1-tert-butyl 2-methyl 2-(4-methoxyphenylcarbamoyl)pyrrolidine-1,2-dicarboxylate

: 1621421-64-4
3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium bromide; sodium tetrahydroborate / methanol / 12 h

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / Sonication

3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

4: triethylamine / ethanol / 0.17 h / Heating; Microwave irradiation

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium bromide; In tetrahydrofuran; methanol; ethanol; dichloromethane;