Technology Process of 3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide
There total 6 articles about 3-hydroxy-N-(4-methoxyphenyl)-2-(2-(4-methoxyphenyl)-1-oxo-2,5-diazaspiro[3.4]octan-5-yl)butanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
ethanol;
for 0.166667h;
Heating;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -45 °C
1.2: 1 h / -45 °C
2.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C
3.1: lithium bromide; sodium tetrahydroborate / methanol / 12 h
4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / Sonication
5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
6.1: triethylamine / ethanol / 0.17 h / Heating; Microwave irradiation
With
4-methyl-morpholine; sodium tetrahydroborate; di-isopropyl azodicarboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium bromide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium bromide; sodium tetrahydroborate / methanol / 12 h
2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / Sonication
3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
4: triethylamine / ethanol / 0.17 h / Heating; Microwave irradiation
With
sodium tetrahydroborate; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium bromide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;