5,6-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine

Base Information

• Chemical Name: 5,6-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine
• CAS No.: 54866-80-7
• Molecular Formula: C₁₈H₁₉N₃O₂S
• Molecular Weight: 341.434

Synonyms:5,6-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine

Chemical Property of 5,6-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine

Chemical Property:

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Technology Process of 5,6-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine

There total 3 articles about 5,6-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-methylthio-5,6-bis(4-methoxyphenyl)-1,2,4-triazine (58848-77-4) → 5,6-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine (54866-80-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 23h; Ambient temperature;

DOI:10.1021/jo01311a007

Reference yield:

1,2-bis(4-methoxyphenyl)-1,2-ethanedione (1226-42-2) → 5,6-Bis-(4-methoxy-phenyl)-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine (54866-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / sodium bicarbonate / methanol / 8 h / 60 °C

2: 91 percent / sodium borohydride / tetrahydrofuran; methanol / 23 h / Ambient temperature

With sodium tetrahydroborate; sodium hydrogencarbonate; In tetrahydrofuran; methanol;

DOI:10.1021/jo01311a007

Reference yield:

→ 5,6-bis-(4-methoxy-phenyl)-3-methylsulfanyl-4,5-dihydro-[1,2,4]triazine (54866-80-7)

Guidance literature:

/BRN= 301731/ (Ib), CH3-Hal/NaOC2H5;

upstream raw materials:

3-methylthio-5,6-bis(4-methoxyphenyl)-1,2,4-triazine

1,2-bis(4-methoxyphenyl)-1,2-ethanedione

Downstream raw materials:

(1S,3aR,6R,6aR)-3,6-Bis-(4-methoxy-phenyl)-1-methyl-6a-methylsulfanyl-6,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-3a,4-dicarboxylic acid dimethyl ester

2-methyl-3-oxo-4,8-dianisyl-6,7-bis(methoxycarbonyl)-1,2,5-triazabicyclo<4.2.0>octa-7-ene

(S)-5,6-Bis-(4-methoxy-phenyl)-2-methyl-3-methylsulfanyl-2,5-dihydro-[1,2,4]triazine

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