6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane

Base Information

Chemical Name:6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane
CAS No.:1425936-84-0
Molecular Formula:C₃₉H₆₄ClN₅O₁₂S
Molecular Weight:862.482
Hs Code.:

6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane

Synonyms:6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane

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Chemical Property of 6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane

Chemical Property:

Purity/Quality:

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Technology Process of 6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane

There total 3 articles about 6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10130-89-9
p-carboxyphenylsulfonyl chloride

: 1425936-84-0
6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / ethyl acetate; water; tetrahydrofuran / 5 h / 20 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux

2.2: 1 h / 20 °C

3.1: toluene / 3 h / Reflux

3.2: 18 h / 20 °C

With thionyl chloride; sodium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene; 3.1: |Curtius Rearrangement;
DOI:10.1039/c2ob27200h

Reference yield:

: 716358-48-4
4-{[(2-hydroxyethyl)amino]sulfonyl}benzoic acid

: 1425936-84-0
6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux

1.2: 1 h / 20 °C

2.1: toluene / 3 h / Reflux

2.2: 18 h / 20 °C

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; toluene; 2.1: |Curtius Rearrangement;
DOI:10.1039/c2ob27200h

Reference yield:

: 1173766-95-4
1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]amino-6-hydroxymethylperhydro-1,4-diazepine

: 1425936-91-9
4-{[(2-chloroethyl)amino]sulfonyl}benzoyl azide

: 1425936-84-0
6-[(2-chloroethyl)aminosulfonylphenyl]-4-carbamoylmethyl-1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]-amino-1,4-diazepane

Guidance literature:: 4-{[(2-chloroethyl)amino]sulfonyl}benzoyl azide; In toluene; for 3h; Reflux;

1,4-bis(t-butoxycarbonylmethyl)-6-[bis(t-butoxycarbonylmethyl)]amino-6-hydroxymethylperhydro-1,4-diazepine; In dichloromethane; toluene; at 20 ℃; for 18h;
DOI:10.1039/c2ob27200h