2-[trans-4-(2-azidopropoxy)cyclohexyl]-6-(cyclopropylmethoxy)-1-benzofuran

Base Information

Chemical Name:2-[trans-4-(2-azidopropoxy)cyclohexyl]-6-(cyclopropylmethoxy)-1-benzofuran
CAS No.:1344685-16-0
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

Synonyms:2-[trans-4-(2-azidopropoxy)cyclohexyl]-6-(cyclopropylmethoxy)-1-benzofuran

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Chemical Property of 2-[trans-4-(2-azidopropoxy)cyclohexyl]-6-(cyclopropylmethoxy)-1-benzofuran

Chemical Property:

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Technology Process of 2-[trans-4-(2-azidopropoxy)cyclohexyl]-6-(cyclopropylmethoxy)-1-benzofuran

There total 11 articles about 2-[trans-4-(2-azidopropoxy)cyclohexyl]-6-(cyclopropylmethoxy)-1-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344685-15-9
2-({trans-4-[6-(cyclopropylmethoxy)-1-benzofuran-2-yl]cyclohexyl}oxy)-1-methylethyl methanesulfonate

: 1344685-16-0
2-[trans-4-(2-azidopropoxy)cyclohexyl]-6-(cyclopropylmethoxy)-1-benzofuran

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1344685-16-0
2-[trans-4-(2-azidopropoxy)cyclohexyl]-6-(cyclopropylmethoxy)-1-benzofuran

Guidance literature:: Multi-step reaction with 11 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 10 - 35 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Cooling with ice

2.2: 1.5 h / 10 - 35 °C

3.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 3 h / 10 - 35 °C

4.1: potassium carbonate / methanol / 2 h / 10 - 35 °C

5.1: N,N,N',N'-tetramethylguanidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 10 - 35 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 - 35 °C

7.1: potassium tert-butylate / tetrahydrofuran / 10 - 35 °C

8.1: toluene; tetrahydrofuran / 1 h / 0 °C / Cooling with ice

9.1: ethanol; sodium tetrahydroborate / 1 h / 0 °C / Cooling with ice

10.1: triethylamine / tetrahydrofuran / 1 h / 10 - 35 °C

11.1: sodium azide / N,N-dimethyl-formamide / 60 °C

With 1H-imidazole; sodium tetrahydroborate; copper(l) iodide; lithium aluminium tetrahydride; sodium azide; ethanol; potassium tert-butylate; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; N,N,N',N'-tetramethylguanidine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 956122-83-1
ethyl 4-{[tert-butyl(diphenyl)silyl]oxy}cyclohexanecarboxylate

: 1344685-16-0
2-[trans-4-(2-azidopropoxy)cyclohexyl]-6-(cyclopropylmethoxy)-1-benzofuran

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Cooling with ice

1.2: 1.5 h / 10 - 35 °C

2.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 3 h / 10 - 35 °C

3.1: potassium carbonate / methanol / 2 h / 10 - 35 °C

4.1: N,N,N',N'-tetramethylguanidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 10 - 35 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 - 35 °C

6.1: potassium tert-butylate / tetrahydrofuran / 10 - 35 °C

7.1: toluene; tetrahydrofuran / 1 h / 0 °C / Cooling with ice

8.1: ethanol; sodium tetrahydroborate / 1 h / 0 °C / Cooling with ice

9.1: triethylamine / tetrahydrofuran / 1 h / 10 - 35 °C

10.1: sodium azide / N,N-dimethyl-formamide / 60 °C

With sodium tetrahydroborate; copper(l) iodide; lithium aluminium tetrahydride; sodium azide; ethanol; potassium tert-butylate; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; N,N,N',N'-tetramethylguanidine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;