4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenol

Base Information

• Chemical Name: 4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenol
• CAS No.: 1186484-71-8
• Molecular Formula: C₂₃H₁₃F₅N₆O
• Molecular Weight: 484.388

Synonyms:4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenol

Chemical Property of 4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of 4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenol

There total 1 articles about 4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aqueous potassium carbonate + 4-hydroxy-2-trifluomethybenzene boronic acid + 5-((6-chloropyridazin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine (1186482-08-5) → 4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenol (1186484-71-8)

Guidance literature:

Pd(PPh₃)4; In 1,4-dioxane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

1-bromo-2-methyl-butane (10422-35-2,99032-67-4,534-00-9,5973-11-5) + 4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenol (1186484-71-8) → 2-(2,3-Difluoro-phenyl)-5-{6-[4-(2-methyl-butoxy)-2-trifluoromethyl-phenyl]-pyridazin-3-ylmethyl}-5H-imidazo[4,5-d]pyridazine

Guidance literature:

Reference yield:

4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenol (1186484-71-8) → trifluoro-methanesulfonic acid 4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenyl ester (1186484-75-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

upstream raw materials:

5-((6-chloropyridazin-3-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

Downstream raw materials:

5-[6-(4-Cyclopropylmethoxy-2-trifluoromethyl-phenyl)-pyridazin-3-ylmethyl]-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine

2-(2,3-Difluoro-phenyl)-5-{6-[4-(3-methyl-butoxy)-2-trifluoromethyl-phenyl]-pyridazin-3-ylmethyl}-5H-imidazo[4,5-d]pyridazine

1-(4-{6-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-pyridazin-3-yl}-3-trifluoromethyl-phenoxy)-propan-2-one

2-(2,3-Difluoro-phenyl)-5-{6-[4-(2-methoxy-ethoxy)-2-trifluoromethyl-phenyl]-pyridazin-3-ylmethyl}-5H-imidazo[4,5-d]pyridazine

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