2-(3-(6-amino-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)phenoxy)-N-isopropylacetamide

Base Information

Chemical Name:2-(3-(6-amino-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)phenoxy)-N-isopropylacetamide
CAS No.:1595291-29-4
Molecular Formula:C₂₀H₂₈N₆O₂
Molecular Weight:384.481
Hs Code.:

Synonyms:2-(3-(6-amino-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)phenoxy)-N-isopropylacetamide

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Chemical Property of 2-(3-(6-amino-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)phenoxy)-N-isopropylacetamide

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Technology Process of 2-(3-(6-amino-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)phenoxy)-N-isopropylacetamide

There total 3 articles about 2-(3-(6-amino-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)phenoxy)-N-isopropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 109-01-3
1-methyl-piperazine

: 1595291-27-2
2-(3-(6-amino-2-chloropyrimidin-4-yl)phenoxy)-N-isopropylacetamide

: 1595291-29-4
2-(3-(6-amino-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)phenoxy)-N-isopropylacetamide

Guidance literature:: In butan-1-ol; at 120 ℃; Inert atmosphere;

Reference yield:

: 75726-96-4
2-bromo-N-isopropylacetamide

: 1595291-29-4
2-(3-(6-amino-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)phenoxy)-N-isopropylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

3: butan-1-ol / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; cesium fluoride; In 1,4-dioxane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1595290-47-3
N-isopropyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetamide

: 1595291-29-4
2-(3-(6-amino-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)phenoxy)-N-isopropylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

2: butan-1-ol / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In 1,4-dioxane; water; butan-1-ol;