carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>>

Base Information

• Chemical Name: carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>>
• CAS No.: 153805-38-0
• Molecular Formula: C₃₅H₆₀N₄O₆S
• Molecular Weight: 664.951

Synonyms:carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>>

Chemical Property of carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>>

There total 5 articles about carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2(R)-<5(R)-<1(S)-<(tert-butyloxycarbonyl)amino>-2-cyclohexylethyl>-2,2-dimethyl-4(R)-dioxolanyl>-3-methylbutanoic acid (112190-45-1) + 5-thiazolylethanamine, 4-methyl-N-(2-amino-3-methyl-1-oxopentyl)-, <2S-(R*,R*)>- (153805-37-9) → carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>> (153805-38-0)

Guidance literature:

With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 14h; Ambient temperature;

DOI:10.1021/jm00028a013

Reference yield:

5-hydroxyethyl-4-methylthiazole (137-00-8,8042-97-5) → carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>> (153805-38-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 54 percent / ZnN₆-pyridine2, PPh₃, diisopropyl azodicarboxylate / toluene / 3 h / Ambient temperature

2: 97 percent / H₂ / Pd/CaCO₃ / methanol / 2.5 h / 760 Torr

3: 97 percent / iPr₂EtN, (EtO)2P(O)CN / CH₂Cl₂ / 20 h / Ambient temperature

4: 91 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / Ambient temperature

5: 80 percent / iPr₂EtN, (EtO)2P(O)CN / CH₂Cl₂ / 14 h / Ambient temperature

With diethyl cyanophosphonate; di-isopropyl azodicarboxylate; ZnN₆-pyridine2; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; Lindlar's catalyst; In methanol; dichloromethane; toluene;

DOI:10.1021/jm00028a013

Reference yield:

5-(2-azidoethyl)-4-methylthiazole (153805-36-8) → carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>> (153805-38-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / H₂ / Pd/CaCO₃ / methanol / 2.5 h / 760 Torr

2: 97 percent / iPr₂EtN, (EtO)2P(O)CN / CH₂Cl₂ / 20 h / Ambient temperature

3: 91 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / Ambient temperature

4: 80 percent / iPr₂EtN, (EtO)2P(O)CN / CH₂Cl₂ / 14 h / Ambient temperature

With diethyl cyanophosphonate; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; Lindlar's catalyst; In methanol; dichloromethane;

DOI:10.1021/jm00028a013

upstream raw materials:

2(R)-<5(R)-<1(S)-<(tert-butyloxycarbonyl)amino>-2-cyclohexylethyl>-2,2-dimethyl-4(R)-dioxolanyl>-3-methylbutanoic acid

5-thiazolylethanamine, 4-methyl-N-(2-amino-3-methyl-1-oxopentyl)-, <2S-(R*,R*)>-

5-hydroxyethyl-4-methylthiazole

VUF 8952

Downstream raw materials:

L-idonamide, 6-cyclohexyl-2,5,6-trideoxy-5-amino-2-(1-methylethyl)-N-<2-methyl-1-<<<2-(4-methyl-5-thiazolyl)ethyl>amino>carbonyl>butyl>-, <3aS-<3aα,4β(1R*,2R*),6aα>>-

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 153805-38-0 carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>>

Send

Send

Metric Ton KG G Pound L ML

Send

Send