ethyl 11-benzyl-9-[(ethoxycarbonyl)methyl]-1-oxo-1,2,3,9,10,11-hexahydro[1,4]oxazino[3,2-f]pyrrolo[3,2,1-ij]quinoline-5-carboxylate

Base Information

Chemical Name:ethyl 11-benzyl-9-[(ethoxycarbonyl)methyl]-1-oxo-1,2,3,9,10,11-hexahydro[1,4]oxazino[3,2-f]pyrrolo[3,2,1-ij]quinoline-5-carboxylate
CAS No.:462117-45-9
Molecular Formula:C₂₇H₂₈N₂O₆
Molecular Weight:476.529
Hs Code.:

Synonyms:ethyl 11-benzyl-9-[(ethoxycarbonyl)methyl]-1-oxo-1,2,3,9,10,11-hexahydro[1,4]oxazino[3,2-f]pyrrolo[3,2,1-ij]quinoline-5-carboxylate

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Chemical Property of ethyl 11-benzyl-9-[(ethoxycarbonyl)methyl]-1-oxo-1,2,3,9,10,11-hexahydro[1,4]oxazino[3,2-f]pyrrolo[3,2,1-ij]quinoline-5-carboxylate

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Technology Process of ethyl 11-benzyl-9-[(ethoxycarbonyl)methyl]-1-oxo-1,2,3,9,10,11-hexahydro[1,4]oxazino[3,2-f]pyrrolo[3,2,1-ij]quinoline-5-carboxylate

There total 5 articles about ethyl 11-benzyl-9-[(ethoxycarbonyl)methyl]-1-oxo-1,2,3,9,10,11-hexahydro[1,4]oxazino[3,2-f]pyrrolo[3,2,1-ij]quinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 462117-43-7
3-{2-[(ethoxycarbonyl)methyl]-4-benzyl-7-(ethoxycarbonyl)-2,3,4,6-tetrahydro[1,4]oxazino[2,3-f]indol-6-yl}propanoic acid

: 462117-45-9
ethyl 11-benzyl-9-[(ethoxycarbonyl)methyl]-1-oxo-1,2,3,9,10,11-hexahydro[1,4]oxazino[3,2-f]pyrrolo[3,2,1-ij]quinoline-5-carboxylate

Guidance literature:: With PPSE; In 1,2-dichloro-ethane; for 2h; Heating;
DOI:10.1002/1099-0690(200205)2002:10<1646::AID-EJOC1646>3.0.CO;2-K

Reference yield:

: ethyl 4-benzyl-7-formyl-2,3-dihydro-1,4-benzoxazine-2-acetate

: 462117-45-9
ethyl 11-benzyl-9-[(ethoxycarbonyl)methyl]-1-oxo-1,2,3,9,10,11-hexahydro[1,4]oxazino[3,2-f]pyrrolo[3,2,1-ij]quinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium ethoxide / ethanol / 20 h / -18 °C

2: xylene / Heating

3: 94 percent / Triton B / dimethylformamide; H₂O / 4 h / 20 °C

4: 97 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

5: 86 percent / PPSE / 1,2-dichloro-ethane / 2 h / Heating

With sodium ethanolate; N-benzyl-trimethylammonium hydroxide; trifluoroacetic acid; In ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; xylene; 1: Hemetsberger reaction / 2: Hemetsberger reaction;
DOI:10.1002/1099-0690(200205)2002:10<1646::AID-EJOC1646>3.0.CO;2-K

Reference yield:

: 2-azido-3-(4-benzyl-2-ethoxycarbonylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acrylic acid ethyl ester

: 462117-45-9
ethyl 11-benzyl-9-[(ethoxycarbonyl)methyl]-1-oxo-1,2,3,9,10,11-hexahydro[1,4]oxazino[3,2-f]pyrrolo[3,2,1-ij]quinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: xylene / Heating

2: 94 percent / Triton B / dimethylformamide; H₂O / 4 h / 20 °C

3: 97 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

4: 86 percent / PPSE / 1,2-dichloro-ethane / 2 h / Heating

With N-benzyl-trimethylammonium hydroxide; trifluoroacetic acid; In dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; xylene; 1: Hemetsberger reaction;
DOI:10.1002/1099-0690(200205)2002:10<1646::AID-EJOC1646>3.0.CO;2-K