Technology Process of 4-Piperidineethanol,2-(1-methylethyl)-,(2R,4S)-rel-(9CI)
There total 18 articles about 4-Piperidineethanol,2-(1-methylethyl)-,(2R,4S)-rel-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-[1-Ethoxycarbonyl-meth-(E)-ylidene]-2-isopropyl-piperidine-1-carboxylic acid tert-butyl ester;
With
trifluoroacetic acid;
In
dichloromethane;
for 2h;
With
ammonia; lithium;
In
tetrahydrofuran;
at -78 - -18 ℃;
Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ol006589o
- Guidance literature:
-
4-[1-Ethoxycarbonyl-meth-(E)-ylidene]-2-isopropyl-piperidine-1-carboxylic acid tert-butyl ester;
With
trifluoroacetic acid;
In
dichloromethane;
for 2h;
With
ammonia; lithium;
In
tetrahydrofuran;
at -78 - -18 ℃;
Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ol006589o
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / -20 °C
2.1: -78 °C
2.2: aq. HCl / 23 °C
3.1: sodium methoxide / methanol / 2 h / 23 °C
4.1: DMAP / acetonitrile / 23 °C
5.1: 86 percent / Zn / acetic acid / 50 °C
6.1: 93 percent / toluene / Heating
7.1: trifluoroacetic acid / CH2Cl2 / 2 h
7.2: lithium; NH3 / tetrahydrofuran / -78 - -18 °C
With
dmap; sodium methylate; trifluoroacetic acid; zinc;
In
tetrahydrofuran; methanol; dichloromethane; acetic acid; toluene; acetonitrile;
1.1: Acylation / 2.1: Grignard reaction / 2.2: Hydrolysis / 3.1: Hydrolysis / 4.1: Acylation / 5.1: Reduction / 6.1: Wittig reaction / 7.1: Elimination / 7.2: Elimination;
DOI:10.1021/ol006589o
