N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>ethylamino>benzoyl>-L-glutamic acid diethyl ester

Base Information

Chemical Name:N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>ethylamino>benzoyl>-L-glutamic acid diethyl ester
CAS No.:101810-78-0
Molecular Formula:C₂₇H₃₅N₇O₅
Molecular Weight:537.619
Hs Code.:

Synonyms:N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>ethylamino>benzoyl>-L-glutamic acid diethyl ester

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Chemical Property of N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>ethylamino>benzoyl>-L-glutamic acid diethyl ester

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Technology Process of N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>ethylamino>benzoyl>-L-glutamic acid diethyl ester

There total 1 articles about N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>ethylamino>benzoyl>-L-glutamic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70280-71-6
diethyl N-<4-(ethylamino)benzoyl>-L-glutamate

: 101810-75-7
6-(bromomethyl)-2,4-diamino-5-methylpyrido<2,3-d>pyrimidine hydrobromide

: 101810-78-0
N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>ethylamino>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: In N,N-dimethyl acetamide; at 22 - 25 ℃; for 144h; Yield given;
DOI:10.1021/jm00156a029

Reference yield: 97.0%

: 101810-78-0
N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>ethylamino>benzoyl>-L-glutamic acid diethyl ester

: 101810-80-4
5-methyl-5-deaza-10-ethylaminopterin

Guidance literature:: With sodium hydroxide; In methanol; 1.) 22 deg C - 25 deg C, 48 h, 2.) 45 deg C - 50 deg C, 1 h, 3.) 22 deg C - 25 deg C, 17 h;
DOI:10.1021/jm00156a029