1-(3,5-bis(trifluoromethyl)phenyl)-3-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)urea

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Chemical Name:1-(3,5-bis(trifluoromethyl)phenyl)-3-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)urea
CAS No.:1372971-95-3
Molecular Formula:C₃₀H₃₃F₆N₃O₂Si
Molecular Weight:609.687
Hs Code.:

Synonyms:1-(3,5-bis(trifluoromethyl)phenyl)-3-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)urea

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Chemical Property of 1-(3,5-bis(trifluoromethyl)phenyl)-3-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)urea

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Technology Process of 1-(3,5-bis(trifluoromethyl)phenyl)-3-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)urea

There total 8 articles about 1-(3,5-bis(trifluoromethyl)phenyl)-3-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1372972-14-9
C₃₅H₄₁F₆N₃O₄Si

: 1372971-95-3
1-(3,5-bis(trifluoromethyl)phenyl)-3-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)urea

Guidance literature:: C₃₅H₄₁F₆N₃O₄Si; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 6h;

With ammonia; In water; pH=8;
DOI:10.1039/c2ob00049k

Reference yield:

: 1159114-52-9
tert-butyl (2S,4R)-4-azido-2-(((tert-butyldiphenylsilyl)oxy)methyl)pyrrolidine-1-carboxylate

: 1372971-95-3
1-(3,5-bis(trifluoromethyl)phenyl)-3-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / water

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h

3.1: trifluoroacetic acid / dichloromethane / 6 h / 0 °C

3.2: pH 8

With N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; water;
DOI:10.1039/c2ob00049k

Reference yield:

: 1159114-51-8
tert-butyl (2S,4S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-4-((methylsulfonyl)oxy)-pyrrolidine-1-carboxylate

: 1372971-95-3
1-(3,5-bis(trifluoromethyl)phenyl)-3-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / N,N-dimethyl-formamide

2.1: triphenylphosphine / water

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 °C

4.2: pH 8

With sodium azide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob00049k