Technology Process of Methyl 13-cyclohexyl-10-((((dimethylamino)sulfonyl)amino)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-6-carboxylate 9-oxide
There total 9 articles about Methyl 13-cyclohexyl-10-((((dimethylamino)sulfonyl)amino)carbonyl)-3-(methyloxy)-7H-pyrido[3',2':4,5]pyrrolo[2,1-a][2]benzazepine-6-carboxylate 9-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 65 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; ethanol / 144 h
2.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 4 h / Heating / reflux
3.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane / 1 h / 20 °C
3.2: 1.17 h / 20 °C
4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
4.2: 2 h / 50 °C
4.3: 2.5 h / 20 °C
5.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / palladium diacetate / toluene / 2 h / Heating / reflux
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 22 h / Heating / reflux
7.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; pyridinium hydrobromide perbromide; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
palladium diacetate; 20% Pd(OH)2 on carbon;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;
5.1: Suzuki Coupling / 7.1: Horner Emmons reaction;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 4 h / Heating / reflux
2.1: 3-chloro-benzenecarboperoxoic acid / 1,2-dimethoxyethane / 1 h / 20 °C
2.2: 1.17 h / 20 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
3.2: 2 h / 50 °C
3.3: 2.5 h / 20 °C
4.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / palladium diacetate / toluene / 2 h / Heating / reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 22 h / Heating / reflux
6.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; pyridinium hydrobromide perbromide; tetrabutyl ammonium fluoride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
palladium diacetate;
In
tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;
4.1: Suzuki Coupling / 6.1: Horner Emmons reaction;
