Technology Process of 11-deaza-10-methyl-7,8-dihydrohomofolate
There total 11 articles about 11-deaza-10-methyl-7,8-dihydrohomofolate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 56 percent / CH2Cl2 / 40 h / Ambient temperature
2: 41 percent / CuBr / tetrahydrofuran / a) -25 deg C, 2 h, b) r.t., 12 h
3: 99 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating
4: 83 percent / hydrazine / methanol / 48 h
5: 75 percent / methylmorpholine / methanol / 3 h / Heating
6: 1N HCl, TFA / 60 °C
8: 50 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide; dimethylsulfoxide / 18 h / solid phase coupling
9: H2 / PtO2 / 14 h / 760 Torr / pH 7.0
With
4-methyl-morpholine; 2-methylmorpholine; pyridine; hydrogenchloride; hydroxylamine hydrochloride; hydrogen; trifluoroacetic acid; copper(I) bromide; hydrazine; isobutyl chloroformate;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / methylmorpholine / methanol / 3 h / Heating
2: 1N HCl, TFA / 60 °C
4: 50 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide; dimethylsulfoxide / 18 h / solid phase coupling
5: H2 / PtO2 / 14 h / 760 Torr / pH 7.0
With
4-methyl-morpholine; 2-methylmorpholine; hydrogenchloride; hydrogen; trifluoroacetic acid; isobutyl chloroformate;
platinum(IV) oxide;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 50 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide; dimethylsulfoxide / 18 h / solid phase coupling
2: H2 / PtO2 / 14 h / 760 Torr / pH 7.0
With
4-methyl-morpholine; hydrogen; isobutyl chloroformate;
platinum(IV) oxide;
In
dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a022
