1-Benzyl-2-piperazin-1-yl-1H-benzo[4,5]thieno[2,3-d]imidazole

Base Information

• Chemical Name: 1-Benzyl-2-piperazin-1-yl-1H-benzo[4,5]thieno[2,3-d]imidazole
• CAS No.: 166828-77-9
• Molecular Formula: C₂₀H₂₀N₄S
• Molecular Weight: 348.472
• Mol file: 166828-77-9.mol

Synonyms:1-Benzyl-2-piperazin-1-yl-1H-benzo[4,5]thieno[2,3-d]imidazole

Chemical Property of 1-Benzyl-2-piperazin-1-yl-1H-benzo[4,5]thieno[2,3-d]imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-2-piperazin-1-yl-1H-benzo[4,5]thieno[2,3-d]imidazole

There total 3 articles about 1-Benzyl-2-piperazin-1-yl-1H-benzo[4,5]thieno[2,3-d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-(1-Benzyl-1H-benzo[4,5]thieno[2,3-d]imidazol-2-yl)-piperazine-1-carboxylic acid ethyl ester (166828-73-5) → 1-Benzyl-2-piperazin-1-yl-1H-benzo[4,5]thieno[2,3-d]imidazole (166828-77-9)

Guidance literature:

With hydrogen bromide; for 3h; Heating;

DOI:10.1002/jhet.5570320237

Reference yield:

2-nitro-3-N-benzylaminobenzothiophene (58763-85-2) → 1-Benzyl-2-piperazin-1-yl-1H-benzo[4,5]thieno[2,3-d]imidazole (166828-77-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 2.) H₂ / 2.) Pd/C

2: 74 percent / 2,4,4,6-tetrabromo-2,5-cyclohexadienone / ethanol / Ambient temperature

3: 81 percent / 48 h / 120 °C

4: 56 percent / 48percent aq. HBr / 3 h / Heating

With 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one; hydrogen bromide; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1002/jhet.5570320237

Reference yield:

1-Benzyl-2-bromo-1H-benzo[4,5]thieno[2,3-d]imidazole (166828-69-9) → 1-Benzyl-2-piperazin-1-yl-1H-benzo[4,5]thieno[2,3-d]imidazole (166828-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 48 h / 120 °C

2: 56 percent / 48percent aq. HBr / 3 h / Heating

With hydrogen bromide;

DOI:10.1002/jhet.5570320237

upstream raw materials:

4-(1-Benzyl-1H-benzo[4,5]thieno[2,3-d]imidazol-2-yl)-piperazine-1-carboxylic acid ethyl ester

2-nitro-3-N-benzylaminobenzothiophene

1-Benzyl-2-bromo-1H-benzo[4,5]thieno[2,3-d]imidazole