3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide

Base Information

Chemical Name:3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide
CAS No.:1423161-85-6
Molecular Formula:C₂₀H₁₉BrN₄O₄S₂
Molecular Weight:523.431
Hs Code.:

Synonyms:3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide

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Chemical Property of 3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide

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Technology Process of 3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide

There total 5 articles about 3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1063733-41-4
N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

: 1423161-84-5
3-bromo-1-methyl-1H-indole-6-sulfonyl chloride

: 1423161-85-6
3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide

Guidance literature:: N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

3-bromo-1-methyl-1H-indole-6-sulfonyl chloride; In tetrahydrofuran; for 2h; Inert atmosphere;

Reference yield:

: 52415-29-9
6-bromo-1H-indole

: 1423161-85-6
3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with acetone-dry ice

2.2: 0.58 h / 0 °C / Inert atmosphere; Cooling with acetone-dry ice

2.3: 0.25 h / 0 °C

3.1: N-Bromosuccinimide / dichloromethane / 2.5 h / Darkness

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere

With N-Bromosuccinimide; n-butyllithium; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 1041469-95-7
1-methyl-1H-indole-6-sulfonyl chloride

: 1423161-85-6
3-bromo-N-(2,4-dimethoxybenzyl)-1-methyl-N-(1,2,4-thiadiazol-5-yl)-1H-indole-6-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / dichloromethane / 2.5 h / Darkness

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere

With N-Bromosuccinimide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;