3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Base Information

• Chemical Name: 3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one
• CAS No.: 168280-55-5
• Molecular Formula: C₁₆H₁₅ClN₄OS
• Molecular Weight: 346.84

Synonyms:3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Chemical Property of 3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Chemical Property:

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Technology Process of 3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

There total 4 articles about 3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(4-chloro-phenyliminomethyleneamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester (1027530-47-7) → 3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (168280-55-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 0.166667h;

DOI:10.1055/s-2005-865289

Reference yield: 48.0%

N1-(3-carbethoxy-4,5,6,7-tetrahydrobenzothien-2-yl)-N2-p-chlorophenylthiourea (111423-07-5) → 3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (168280-55-5)

Guidance literature:

With hydrazine hydrate; for 10h; Heating;

DOI:10.1016/0223-5234(96)88255-9

Reference yield:

p-chlorphenylisocyanate (104-12-1) → 3-amino-2-(4-chlorophenyl)amino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (168280-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0 - 5 °C

2: 74 percent / NH₂NH₂*H₂O / ethanol / 0.17 h / 20 °C

With hydrazine hydrate; In ethanol; dichloromethane; 1: aza-Wittig reaction;

DOI:10.1055/s-2005-865289

upstream raw materials:

N¹-(3-carbethoxy-4,5,6,7-tetrahydrobenzothien-2-yl)-N²-p-chlorophenylthiourea

2-(4-chloro-phenyliminomethyleneamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

p-chlorphenylisocyanate

4,5,6,7-Tetrahydro-2-(triphenylphosphoranylidenamino)benzothiophen-3-carbonsaeure-ethylester

Downstream raw materials:

C₃₄H₂₈ClN₄OPS

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