3-(4-(4-methoxybenzyl)-1-oxophthalazin-2(1H)-yl)-N-(4-sulfamoylphenyl)propanamide

Base Information

Chemical Name:3-(4-(4-methoxybenzyl)-1-oxophthalazin-2(1H)-yl)-N-(4-sulfamoylphenyl)propanamide
CAS No.:1622427-28-4
Molecular Formula:C₂₅H₂₄N₄O₅S
Molecular Weight:492.555
Hs Code.:

Synonyms:3-(4-(4-methoxybenzyl)-1-oxophthalazin-2(1H)-yl)-N-(4-sulfamoylphenyl)propanamide

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Chemical Property of 3-(4-(4-methoxybenzyl)-1-oxophthalazin-2(1H)-yl)-N-(4-sulfamoylphenyl)propanamide

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Technology Process of 3-(4-(4-methoxybenzyl)-1-oxophthalazin-2(1H)-yl)-N-(4-sulfamoylphenyl)propanamide

There total 5 articles about 3-(4-(4-methoxybenzyl)-1-oxophthalazin-2(1H)-yl)-N-(4-sulfamoylphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 57835-95-7
4-[(4-methoxyphenyl)methyl]-1(2H)-phthalazinone

: 104246-29-9
3‐chloro‐N‐(4‐sulfamoylphenyl)propanamide

: 1622427-28-4
3-(4-(4-methoxybenzyl)-1-oxophthalazin-2(1H)-yl)-N-(4-sulfamoylphenyl)propanamide

Guidance literature:: 3‐chloro‐N‐(4‐sulfamoylphenyl)propanamide; With potassium carbonate; In acetone; for 1h; Reflux;

4-[(4-methoxyphenyl)methyl]-1(2H)-phthalazinone; In acetone; for 12h; Reflux;
DOI:10.1016/j.ejmech.2014.08.016

Reference yield:

: 63-74-1
sulfanilamide

: 1622427-28-4
3-(4-(4-methoxybenzyl)-1-oxophthalazin-2(1H)-yl)-N-(4-sulfamoylphenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-dioxane / 2.5 h / 0 - 20 °C

2.1: potassium carbonate / acetone / 1 h / Reflux

2.2: 12 h / Reflux

With potassium carbonate; In 1,4-dioxane; acetone;
DOI:10.1016/j.ejmech.2014.08.016

Reference yield:

: 85-44-9
phthalic anhydride

: 1622427-28-4
3-(4-(4-methoxybenzyl)-1-oxophthalazin-2(1H)-yl)-N-(4-sulfamoylphenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate / 4 h / 240 °C / Dean-Stark

2.1: hydrazinium sulfate; sodium hydroxide / ethanol; water / 3 h / 95 °C

3.1: potassium carbonate / acetone / 1 h / Reflux

3.2: 12 h / Reflux

With sodium acetate; potassium carbonate; sodium hydroxide; hydrazinium sulfate; In ethanol; water; acetone;
DOI:10.1016/j.ejmech.2014.08.016