α-isopropyl-3,4,5-trimethoxy-α-<3--N-propylamino>propyl>benzeneacetonitrile

Base Information

• Chemical Name: α-isopropyl-3,4,5-trimethoxy-α-<3--N-propylamino>propyl>benzeneacetonitrile
• CAS No.: 103525-12-8
• Molecular Formula: C₃₀H₄₄N₂O₅
• Molecular Weight: 512.69
• Mol file: 103525-12-8.mol

Synonyms:α-isopropyl-3,4,5-trimethoxy-α-<3--N-propylamino>propyl>benzeneacetonitrile

Chemical Property of α-isopropyl-3,4,5-trimethoxy-α-<3--N-propylamino>propyl>benzeneacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-isopropyl-3,4,5-trimethoxy-α-<3--N-propylamino>propyl>benzeneacetonitrile

There total 4 articles about α-isopropyl-3,4,5-trimethoxy-α-<3--N-propylamino>propyl>benzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

propyl bromide (106-94-5) + α-isopropyl-3,4,5-trimethoxy-α-<3-<<3-(2-methoxyphenoxy)propyl>amino>propyl>-benzeneacetonitrile (103524-69-2) → α-isopropyl-3,4,5-trimethoxy-α-<3--N-propylamino>propyl>benzeneacetonitrile (103525-12-8)

Guidance literature:

With potassium carbonate; In ethanol; for 11.5h; Heating;

DOI:10.1248/cpb.36.367

Reference yield:

α-isopropyl-3,4,5-trimethoxybenzenacetonitrilie (36622-33-0) → α-isopropyl-3,4,5-trimethoxy-α-<3--N-propylamino>propyl>benzeneacetonitrile (103525-12-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 180.45 g / NaNH₂ / tetrahydrofuran / 3.5 h / Heating

2: 91 percent / (COOH)2*2H₂O / acetone; H₂O / 1.5 h / Heating

3: 2.) NaBH₄ / 1.) MeOH, 1 H, reflux, 2.) MeOH, ice water, 1 h, room temp.

4: 78 percent / K₂CO₃ / ethanol / 11.5 h / Heating

With sodium tetrahydroborate; oxalic acid; potassium carbonate; sodium amide; In tetrahydrofuran; ethanol; water; acetone;

DOI:10.1248/cpb.36.367

Reference yield:

α-(2-formylethyl)-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile (66332-86-3) → α-isopropyl-3,4,5-trimethoxy-α-<3--N-propylamino>propyl>benzeneacetonitrile (103525-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) NaBH₄ / 1.) MeOH, 1 H, reflux, 2.) MeOH, ice water, 1 h, room temp.

2: 78 percent / K₂CO₃ / ethanol / 11.5 h / Heating

With sodium tetrahydroborate; potassium carbonate; In ethanol;

DOI:10.1248/cpb.36.367

upstream raw materials:

propyl bromide

α-isopropyl-3,4,5-trimethoxy-α-<3-<<3-(2-methoxyphenoxy)propyl>amino>propyl>-benzeneacetonitrile

α-isopropyl-3,4,5-trimethoxybenzenacetonitrilie

α-(2-formylethyl)-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile