3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel

Base Information

Chemical Name:3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel
CAS No.:926306-86-7
Molecular Formula:C₄₂H₅₂ClF₂NO₁₅
Molecular Weight:884.322
Hs Code.:

Synonyms:3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel

Chemical Property:

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Technology Process of 3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel

There total 9 articles about 3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₇H₈₆ClF₂NO₁₅Si₂

: 926306-86-7
3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: C₃₅H₄₉ClO₁₀Si

: 926306-86-7
3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

3: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; hydrogen fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 926306-99-2
(3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(2,2-difluorovinyl)azetidin-2-one

: 926306-86-7
3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-propanoyldocetaxel

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium cerium (IV) nitrate; water / acetonitrile / 2 h / -10 °C

2: triethylamine; dmap / dichloromethane / 18 h / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

4: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; dmap; ammonium cerium (IV) nitrate; hydrogen fluoride; water; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007