2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

Base Information

Chemical Name:2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid
CAS No.:1393901-30-8
Molecular Formula:C₂₆H₂₈F₃N₅O₂
Molecular Weight:499.536
Hs Code.:

Synonyms:2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

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Chemical Property of 2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

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Technology Process of 2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

There total 11 articles about 2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1393901-29-5
methyl 2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

: 1393901-30-8
2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

Guidance literature:: methyl 2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 16h;

With hydrogenchloride; In methanol; water; pH=2 - 3;

Reference yield:

: 66370-75-0
methyl (2-iodophenyl)acetate

: 1393901-30-8
2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.17 h / 100 °C / microwave irradiation

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

7.2: pH 2 - 3

With lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;

Reference yield:

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1393901-30-8
2-(2-(2-(2-((3-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc(II) chloride / diethyl ether; tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere

1.2: 20 °C

2.1: sodium iodide; hydrogen iodide / 48 h / Darkness

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 0.17 h / 100 °C / microwave irradiation

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 16 h / 20 °C

7.2: pH 2 - 3

With lithium hydroxide monohydrate; water; hydrogen iodide; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium iodide; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide;