tert-butyl 3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate
• CAS No.: 210223-01-1
• Molecular Formula: C₁₅H₂₇NO₄
• Molecular Weight: 285.384
• Mol file: 210223-01-1.mol

Synonyms:tert-butyl (3R)-3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

There total 6 articles about tert-butyl 3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl (3R)-3-[(E)-3-ethoxy-3-oxoprop-1-enyl]piperidine-1-carboxylate → tert-butyl (3R)-3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate (210223-01-1)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; for 18h;

Reference yield:

ethyl (E)-3-(pyridin-3-yl)acrylate (59607-99-7,28447-17-8) → tert-butyl (3R)-3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate (210223-01-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / H₂ / 5percent rhodium on aluminum oxide / ethanol / 12 h / 60 °C / 3102.9 Torr

3: K₂CO₃ / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With hydrogen; potassium carbonate; Rh/Al₂O₃; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm9706630

Reference yield:

3-(piperidin-3-yl)propionic acid ethyl ester (91017-00-4) → tert-butyl (3R)-3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate (210223-01-1)

Guidance literature:

Multi-step reaction with 2 steps

2: K₂CO₃ / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With potassium carbonate; In tetrahydrofuran; water;

DOI:10.1021/jm9706630

upstream raw materials:

di-tert-butyl dicarbonate

(R)-3-Piperidin-3-yl-propionic acid ethyl ester

3-(piperidin-3-yl)propionic acid ethyl ester

ethyl (E)-3-(pyridin-3-yl)acrylate

Downstream raw materials:

(R,S)-1-{3(R)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({3(S)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}oxy)benzimidazole

(R,R)-1-{3(R)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({3(R)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}oxy)benzimidazole

(S,R)-1-{3(S)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({3(R)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}oxy)benzimidazole

(R)-3-{3-[2-(4-Chloro-phenoxymethyl)-4-hydroxy-benzoimidazol-1-yl]-propyl}-piperidine-1-carboxylic acid tert-butyl ester