(2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol

Base Information

Chemical Name:(2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol
CAS No.:1415609-87-8
Molecular Formula:C₁₉H₂₂O₄
Molecular Weight:314.381
Hs Code.:

Synonyms:(2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol

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Technology Process of (2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol

There total 17 articles about (2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4-((2R,4S,6R)-4-acetoxy-6-(4-acetoxyphenethyl)tetrahydro-2H-pyran-2-yl)phenylacetate

: 1415609-87-8
(2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetlet.2016.06.102

Reference yield: 78.0%

: (2R,4S,6R)-2-(4-methoxyphenethyl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ol

: 1415609-87-8
(2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.12.144

Reference yield:

: (5R)-5-(tert-butyldimethylsilyloxy)-3-hydroxy-1,7-bis(4-methoxyphenyl)heptan-1-one

: 1415609-87-8
(2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen; triethylamine / ethanol / 20 °C / Inert atmosphere

4: boron tribromide / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; boron tribromide; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/j.tetlet.2014.12.144