1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid

Base Information

Chemical Name:1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid
CAS No.:1378026-87-9
Molecular Formula:C₂₈H₂₆FN₅O₅S₂
Molecular Weight:595.675
Hs Code.:

1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid

Synonyms:1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid

There total 4 articles about 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1378026-99-3
C₁₁H₉ClN₂O₂S₂

: 85721-33-1,178489-05-9,189257-90-7
ciprofloxacin

: 1378026-87-9
1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 120 ℃;
DOI:10.1007/s00044-012-0074-2

Reference yield:

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 1378026-87-9
1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / water; ethanol / 4 h / 20 °C

2: sodium nitrite; hydrogenchloride; copper / water / 1 h / 0 - 75 °C

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 120 °C

With hydrogenchloride; copper; sodium hydrogencarbonate; potassium hydroxide; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0074-2

Reference yield:

: 627061-10-3
C₁₁H₁₁N₃O₂S₂

: 1378026-87-9
1-cyclopropyl-6-fluoro-1,4-dihydro-7-[4-{5-(2-oxo-2-(p-methoxyphenyl)ethylthio)-1,3,4-thiadiazol-2-yl}piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium nitrite; hydrogenchloride; copper / water / 1 h / 0 - 75 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 120 °C

With hydrogenchloride; copper; sodium hydrogencarbonate; sodium nitrite; In water; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0074-2