3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine

Base Information

• Chemical Name: 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine
• CAS No.: 138494-30-1
• Molecular Formula: C₂₉H₄₅N₃O₈Si₂
• Molecular Weight: 619.863
• Mol file: 138494-30-1.mol

Synonyms:3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine

Chemical Property of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine

There total 1 articles about 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3',5'-O-(1,1,3,3-tetraisopropyl-disiloxan-1,3-diyl)-2'-O-trimethylsilyl-N4-(4-anisoyl)cytidine (861816-92-4) → 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine (138494-30-1)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; dichloromethane; at 65 ℃;

Reference yield:

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine (138494-30-1) → 3',5'-O-(1,1,3,3-tetraisopropyl-disiloxan-1,3-diyl)-2'-O-(2-tetrahydrofuranyl)-N4-(4-anisoyl)cytidine (861816-93-5)

Guidance literature:

camphor-10-sulfonic acid; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N-anisoylcytidine (138494-30-1) → N-(1-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-chloro-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-4-methoxy-benzamide (138603-20-0)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid / CH₂Cl₂ / Ambient temperature

2: tetraethylammonium hydrogen fluoride / tetrahydrofuran / 1.5 h

3: 87 percent / pyridine

With pyridine; tetraethylammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(01)96193-9

upstream raw materials:

3',5'-O-(1,1,3,3-tetraisopropyl-disiloxan-1,3-diyl)-2'-O-trimethylsilyl-N₄-(4-anisoyl)cytidine

Downstream raw materials:

N-(1-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-chloro-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-4-methoxy-benzamide

3'-O-<(2-cyanoethyl)(diisopropylamino)phosphino>-5'-O-dimethoxytrityl-2'-O-<1-(2-chloroethoxy)ethyl>-N⁴-anisoylcytidine

N⁴-anisoyl-2'-O-<1-(2-chloroethoxy)ethyl>cytidine

Succinic acid mono-{(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-chloro-ethoxy)-ethoxy]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester