N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine

Base Information

Chemical Name:N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine
CAS No.:88105-88-8
Molecular Formula:C₃₂H₄₃N₇O₇
Molecular Weight:637.736
Hs Code.:

N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N<sup>ω</sup>-nitro-L-arginine

Synonyms:N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine

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Technology Process of N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine

There total 9 articles about N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 88105-87-7
N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

: 88105-88-8
N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine

Guidance literature:: With sodium hydroxide; In methanol; at 25 ℃;
DOI:10.1021/jm00369a017

Reference yield:

: 2270-20-4
5-Phenylpentanoic acid

: 88105-88-8
N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂, DMF / 2 h / 60 °C

2: 40 percent / pyridine / CH₂Cl₂ / 3 h / 25 °C

3: 94 percent / H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

4: 35 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / pH 7.0-7.5

5: 94 percent / 2.percent N NaOH / methanol / 25 °C

With pyridine; N-Ethylmaleimide; sodium hydroxide; thionyl chloride; hydrogen; benzotriazol-1-ol; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm00369a017

Reference yield:

: 88105-75-3
N-(5-phenylpentanoyl)-L-proline benzyl ester

: 88105-88-8
N-(5-phenylpentanoyl)-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

2: 35 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / pH 7.0-7.5

3: 94 percent / 2.percent N NaOH / methanol / 25 °C

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00369a017