4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester

Base Information

• Chemical Name: 4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester
• CAS No.: 1191997-39-3
• Molecular Formula: C₁₃H₁₄BrClO₄
• Molecular Weight: 349.609
• Mol file: 1191997-39-3.mol

Synonyms:4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester

Chemical Property of 4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester

There total 1 articles about 4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester (1191997-38-2) → 4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester (1191997-39-3)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 5h; Product distribution / selectivity; Reflux;

Reference yield: 60.0%

(S)-2-amino-3-cyclopentyl-propionic acid methyl ester hydrochloride (1191996-99-2,2514709-11-4) + 4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester (1191997-39-3) → (S)-2-[4-(2-chloro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-3-cyclopentyl-propionic acid methyl ester (1191997-46-2)

Guidance literature:

(S)-2-amino-3-cyclopentyl-propionic acid methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 - 80 ℃;

4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester; In acetonitrile; at 80 - 100 ℃;

Reference yield: 40.0%

2-amino-3-(tetrahydro-pyran-4-yl)-propionic acid methyl ester hydrochloride (1191997-33-7) + 4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester (1191997-39-3) → 2-[4-(2-chloro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-3-(tetrahydro-pyran-4-yl)-propionic acid methyl ester (1191997-43-9)

Guidance literature:

2-amino-3-(tetrahydro-pyran-4-yl)-propionic acid methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 - 80 ℃;

4-bromo-3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester; In acetonitrile; at 80 - 100 ℃;

upstream raw materials:

3-(2-chloro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester

Downstream raw materials:

(S)-2-[4-(2-chloro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-3-cyclohexyl-propionic acid methyl ester

(S)-2-[4-(2-chloro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester

(S)-2-[4-(2-chloro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-3-cyclopentyl-propionic acid methyl ester

2-[4-(2-chloro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-3-(tetrahydro-pyran-4-yl)-propionic acid methyl ester